TY - JOUR
T1 - Association between C-reactive protein and QTc interval in middle-aged men and women
AU - Kim, Eunhee
AU - Joo, Soon Jae
AU - Kim, Jinyoung
AU - Ahn, Jeong Cheon
AU - Kim, Je Hyeong
AU - Kimm, Kuchan
AU - Shin, Chol
N1 - Funding Information:
This study was supported by Center for Genome Science, Korea National Institute of Health, (Budgets 2001-347-6111-221 and 2002-347-6111-221).
PY - 2006/9
Y1 - 2006/9
N2 - Background: Both of prolonged QT interval and elevated C-reactive protein (CRP) levels are known to be risk factors of cardiovascular disease. To our knowledge, few studies have reported the direct relationship between CRP levels and the QT interval in middle-aged population. The objective of the present study was to examine the association of CRP level with QT interval. Methods and results: A total of 2471 men and 2287 women from the Korea n Health and Genome study underwent physical examination and completed a questionnaire. A 12-lead electrocardiogram (ECG) recording was obtained from each subject. Subjects who were taking statins, non-steroidal anti-inflammatory drugs (NSAID) and postmenopausal hormone replacement therapy, which are known to have an effect on CRP levels, were excluded. Geometric means of CRP levels were compared among three groups, which were classified by heart rate-corrected QT (QTc) interval: prolonged (≥440 msec in men and ≥450 msec in women), borderline (420-439 msec in men and 430-449 msec in women) and normal (<420 msec in men and <430 msec in women) groups. The means of CRP level in women, though over normal range, increased significantly as QTc interval was longer, independent of confounding factors, while those of men were on the borderline of significance. However, compared to normal range of QTc interval, prolonged QTc interval was associated with elevated CRP level, defined as more than 95 percentile of CRP, in men and women, respectively. Conclusions: Prolonged QTc interval in middle-aged men and women is associated with the elevated CRP, independent of confounding factors.
AB - Background: Both of prolonged QT interval and elevated C-reactive protein (CRP) levels are known to be risk factors of cardiovascular disease. To our knowledge, few studies have reported the direct relationship between CRP levels and the QT interval in middle-aged population. The objective of the present study was to examine the association of CRP level with QT interval. Methods and results: A total of 2471 men and 2287 women from the Korea n Health and Genome study underwent physical examination and completed a questionnaire. A 12-lead electrocardiogram (ECG) recording was obtained from each subject. Subjects who were taking statins, non-steroidal anti-inflammatory drugs (NSAID) and postmenopausal hormone replacement therapy, which are known to have an effect on CRP levels, were excluded. Geometric means of CRP levels were compared among three groups, which were classified by heart rate-corrected QT (QTc) interval: prolonged (≥440 msec in men and ≥450 msec in women), borderline (420-439 msec in men and 430-449 msec in women) and normal (<420 msec in men and <430 msec in women) groups. The means of CRP level in women, though over normal range, increased significantly as QTc interval was longer, independent of confounding factors, while those of men were on the borderline of significance. However, compared to normal range of QTc interval, prolonged QTc interval was associated with elevated CRP level, defined as more than 95 percentile of CRP, in men and women, respectively. Conclusions: Prolonged QTc interval in middle-aged men and women is associated with the elevated CRP, independent of confounding factors.
KW - C-reactive protein
KW - Epidemiology
KW - QT interval
UR - http://www.scopus.com/inward/record.url?scp=33750928381&partnerID=8YFLogxK
U2 - 10.1007/s10654-006-9034-9
DO - 10.1007/s10654-006-9034-9
M3 - Article
C2 - 17072542
AN - SCOPUS:33750928381
SN - 0393-2990
VL - 21
SP - 653
EP - 659
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 9
ER -
