TY - JOUR
T1 - Association between FCGR3B copy number variations and susceptibility to autoimmune diseases
T2 - a meta-analysis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Seo, Young Ho
AU - Kim, Jae Hoon
AU - Choi, Sung Jae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
N1 - Funding Information:
This study was supported in part by a grant of the Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea (HI13C2124).
Publisher Copyright:
© 2015, Springer Basel.
PY - 2015/9/25
Y1 - 2015/9/25
N2 - Objective: This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (<2 to ≥2) and high FCGR3B CN (>2 to ≤2). Results: In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 % CI = 1.301–1.716, p = 1.0 × 10−9). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 % CI = 1.219–1.801, p = 7.7 × 10−6) and Asians (OR = 1.498, 95 % CI = 1.306–1.717, p = 1.0 × 10−9). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 % CI = 1.562–2.068, p < 1.0 × 10−9), primary Sjogren’s syndrome (pSS; OR = 2.263, 95 % CI = 1.316–3.892, p = 0.003), and Wegener’s granulomatosis (WG; OR = 1.973, 95 % CI = 1.178–3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 % CI = 0.947–1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Conclusions: Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG.
AB - Objective: This study determined whether FCGR3B copy number variations (CNVs) were associated with susceptibility to autoimmune diseases. Methods: A meta-analysis was conducted to determine the association between FCGR3B CNVs and susceptibility to autoimmune diseases by comparing low FCGR3B CN (<2 to ≥2) and high FCGR3B CN (>2 to ≤2). Results: In all, 28 comparative studies from 15 reports involving 12,160 patients and 11,103 controls were included in this meta-analysis. The meta-analysis showed a significant association between low FCGR3B CN and autoimmune diseases (OR = 1.496, 95 % CI = 1.301–1.716, p = 1.0 × 10−9). Subgroup analysis according to ethnicity indicated an association between low FCGR3B CN and autoimmune diseases in Caucasians (OR = 1.482, 95 % CI = 1.219–1.801, p = 7.7 × 10−6) and Asians (OR = 1.498, 95 % CI = 1.306–1.717, p = 1.0 × 10−9). Meta-analysis according to the type of autoimmune disease indicated a significant association of low FCGR3B CN with systemic lupus erythematosus (SLE; OR = 1.797, 95 % CI = 1.562–2.068, p < 1.0 × 10−9), primary Sjogren’s syndrome (pSS; OR = 2.263, 95 % CI = 1.316–3.892, p = 0.003), and Wegener’s granulomatosis (WG; OR = 1.973, 95 % CI = 1.178–3.302, p = 0.010), but not with rheumatoid arthritis (RA; OR = 1.333, 95 % CI = 0.947–1.877, p = 0.099). However, the meta-analysis showed no association between high FCGR3B CN and SLE, RA, pSS, and WG. Conclusions: Thus, the results of this meta-analysis indicated that low FCGR3B CN increased susceptibility to autoimmune diseases, especially SLE, pSS, and WG.
KW - Autoimmune diseases
KW - Copy number variation
KW - FCGR3B
KW - Meta-analysis
UR - http://www.scopus.com/inward/record.url?scp=84945461721&partnerID=8YFLogxK
U2 - 10.1007/s00011-015-0882-1
DO - 10.1007/s00011-015-0882-1
M3 - Article
C2 - 26407570
AN - SCOPUS:84945461721
SN - 1023-3830
VL - 64
SP - 983
EP - 991
JO - Inflammation Research
JF - Inflammation Research
IS - 12
ER -