Association between microbiota and nasal mucosal diseases in terms of immunity

Junhu Tai, Mun Soo Han, Jiwon Kwak, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)

Abstract

The pathogenesis of nasal inflammatory diseases is related to various factors such as anatomical structure, heredity, and environment. The nasal microbiota play a key role in coordinating immune system functions. Dysfunction of the microbiota has a significant impact on the occurrence and development of nasal inflammation. This review will introduce the positive and negative roles of microbiota involved in immunity surrounding nasal mucosal diseases such as chronic sinusitis and allergic rhinitis. In addition, we will also introduce recent developments in DNA sequencing, metabolomics, and proteomics combined with computation-based bioinformatics.

Original languageEnglish
Article number4744
JournalInternational journal of molecular sciences
Volume22
Issue number9
DOIs
Publication statusPublished - 2021 May 1

Bibliographical note

Funding Information:
Funding: This research was supported by the Basic Science Research Program and National Research Foundation of Korea, and was funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575 and NRF-2020R1A2C1006398), and the Ministry of Science and ICT (2020R1C1C1012288), Korea, under the ICT Creative Consilience program (IITP-2021-0-01819) supervised by the IITP (Institute for Information & Communications Technology Planning & Evaluation), the Korea Health Technology R&D Project (HI17C0387), the Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant and a grant from the Korea University Medical Center and Anam Hospital, Seoul, Republic of Korea.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Allergic rhinitis
  • Chronic rhinosinusitis
  • Immunity
  • Microbiota
  • Nasal mucosa

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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