Association between norepinephrine transporter gene polymorphism and major depression

Seung Ho Ryu, Seung Hwan Lee, Heon Jeong Lee, Ji Hyun Cha, Byung Joo Ham, Chang Su Han, Myoung Jin Choi, Min Soo Lee

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)


Noradrenergic and serotonergic abnormalities have long been implicated in patients with major depression. The novel selective norepinephrine reuptake inhibitor reboxetine has been shown to be at least as effective as imipramine, desipramine and fluoxetine in the treatment of major depression. It is suggested that the dysfunction of the norepinephrine transporter (NET) may be related to major depression. Although the transcriptional activity related to the NET gene expression is little known, it may be a good candidate gene for major depression. Therefore, we investigated whether the T-182C polymorphism of the NET gene is associated with major depression in a Korean sample of 112 major depression patients compared with 136 healthy controls. We found a significantly lower frequency in TT genotype in patients with major depression than in normal controls when the genotypes of T-182C polymorphism were classified into two groups: TT group versus TC + CC group (p = 0.019). This result suggests that the T-182C polymorphism in the NET gene might be associated with major depression.

Original languageEnglish
Pages (from-to)174-177
Number of pages4
Issue number4
Publication statusPublished - 2004


  • Association study
  • Major depression
  • Norepinephrine transporter gene
  • Polymorphism

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Psychiatry and Mental health
  • Biological Psychiatry


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