Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: A meta-analysis

Young Ho Lee; Sang Cheol Bae

doi:10.1007/s10067-015-3098-4

Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: A meta-analysis

Young Ho Lee, Sang Cheol Bae

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

The objective of the study was to determine by meta-analysis whether polymorphisms of the gene encoding peptidylarginine deiminase 4 (PADI4) are associated with susceptibility to rheumatoid arthritis (RA). A literature review was conducted to identify data sets that described analyses of genetic association between PADI4 polymorphisms and RA. Data sets were collated and a meta-analysis was performed, with a specific focus on associations within Caucasian and Asian populations. A total of 15,947 RA cases and 22,696 controls that were taken from 28 studies in 24 papers were included in this study. Meta-analysis showed a significant association between allele 2 of the PADI4_94 polymorphism and RA in the overall population (odds ratio [OR]= 1.155, 95% confidence interval [CI]=1.069–1.249, p=2.7× 10⁻⁵). Stratification by ethnicity revealed an association between PADI4_94 allele 2 and RA in Asians (OR=1.273, 95% CI=1.193–1.359, p<1.0×10⁻⁹), but not in Caucasians (OR= 1.024, 95% CI=0.973–1.078, p=0.358). However, metaanalysis using homozygote contrast showed an association between PADI4_94 allele 2 and RA in both Asians (OR= 2.311, 95% CI= 1.1.858–2.875, p<1.0×10⁻⁹) and Caucasians (OR=1.523, 95% CI=1.157–2.004, p=0.008). Meta-analysis also revealed an association between allele 2 of the PADI4_104 polymorphism and RA in both Asians (OR=1.547, 95% CI=1.247–1.919, p=7.1×10⁻⁶) and Caucasians (OR=1.096, 95% CI=1.025–1.172, p=0.008). Finally, meta-analysis showed an association between allele 2 of the PADI4_92 polymorphism and RA in Asians (OR= 1.263, 95% CI=1.153–1.384, p=5.8×10⁻⁸), but not in Caucasians (OR=1.123, 95% CI=0.980–1.287, p=0.095). Meta-analysis indicated no association between allele 2 of either the PADI4_90 or PADI4_89 polymorphisms and RA in Asians. This meta-analysis revealed that the PADI4_94 and PADI_104 polymorphisms are associated with susceptibility to RA in Asians and Caucasians, and that the PADI4_92 polymorphism is associated with susceptibility to RA in Asians, but not in Caucasians.

Original language	English
Pages (from-to)	961-971
Number of pages	11
Journal	Clinical Rheumatology
Volume	35
Issue number	4
DOIs	https://doi.org/10.1007/s10067-015-3098-4
Publication status	Published - 2016 Apr 1
Externally published	Yes

Bibliographical note

Publisher Copyright:
© International League of Associations for Rheumatology (ILAR) 2015.

Keywords

Meta-analysis
PADI4
Polymorphism
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology

Access to Document

10.1007/s10067-015-3098-4

Cite this

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title = "Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: A meta-analysis",

abstract = "The objective of the study was to determine by meta-analysis whether polymorphisms of the gene encoding peptidylarginine deiminase 4 (PADI4) are associated with susceptibility to rheumatoid arthritis (RA). A literature review was conducted to identify data sets that described analyses of genetic association between PADI4 polymorphisms and RA. Data sets were collated and a meta-analysis was performed, with a specific focus on associations within Caucasian and Asian populations. A total of 15,947 RA cases and 22,696 controls that were taken from 28 studies in 24 papers were included in this study. Meta-analysis showed a significant association between allele 2 of the PADI4_94 polymorphism and RA in the overall population (odds ratio [OR]= 1.155, 95% confidence interval [CI]=1.069–1.249, p=2.7× 10−5). Stratification by ethnicity revealed an association between PADI4_94 allele 2 and RA in Asians (OR=1.273, 95% CI=1.193–1.359, p<1.0×10−9), but not in Caucasians (OR= 1.024, 95% CI=0.973–1.078, p=0.358). However, metaanalysis using homozygote contrast showed an association between PADI4_94 allele 2 and RA in both Asians (OR= 2.311, 95% CI= 1.1.858–2.875, p<1.0×10−9) and Caucasians (OR=1.523, 95% CI=1.157–2.004, p=0.008). Meta-analysis also revealed an association between allele 2 of the PADI4_104 polymorphism and RA in both Asians (OR=1.547, 95% CI=1.247–1.919, p=7.1×10−6) and Caucasians (OR=1.096, 95% CI=1.025–1.172, p=0.008). Finally, meta-analysis showed an association between allele 2 of the PADI4_92 polymorphism and RA in Asians (OR= 1.263, 95% CI=1.153–1.384, p=5.8×10−8), but not in Caucasians (OR=1.123, 95% CI=0.980–1.287, p=0.095). Meta-analysis indicated no association between allele 2 of either the PADI4_90 or PADI4_89 polymorphisms and RA in Asians. This meta-analysis revealed that the PADI4_94 and PADI_104 polymorphisms are associated with susceptibility to RA in Asians and Caucasians, and that the PADI4_92 polymorphism is associated with susceptibility to RA in Asians, but not in Caucasians.",

keywords = "Meta-analysis, PADI4, Polymorphism, Rheumatoid arthritis",

author = "Lee, {Young Ho} and Bae, {Sang Cheol}",

note = "Publisher Copyright: {\textcopyright} International League of Associations for Rheumatology (ILAR) 2015.",

year = "2016",

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day = "1",

doi = "10.1007/s10067-015-3098-4",

language = "English",

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T1 - Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms

T2 - A meta-analysis

AU - Lee, Young Ho

AU - Bae, Sang Cheol

N1 - Publisher Copyright: © International League of Associations for Rheumatology (ILAR) 2015.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - The objective of the study was to determine by meta-analysis whether polymorphisms of the gene encoding peptidylarginine deiminase 4 (PADI4) are associated with susceptibility to rheumatoid arthritis (RA). A literature review was conducted to identify data sets that described analyses of genetic association between PADI4 polymorphisms and RA. Data sets were collated and a meta-analysis was performed, with a specific focus on associations within Caucasian and Asian populations. A total of 15,947 RA cases and 22,696 controls that were taken from 28 studies in 24 papers were included in this study. Meta-analysis showed a significant association between allele 2 of the PADI4_94 polymorphism and RA in the overall population (odds ratio [OR]= 1.155, 95% confidence interval [CI]=1.069–1.249, p=2.7× 10−5). Stratification by ethnicity revealed an association between PADI4_94 allele 2 and RA in Asians (OR=1.273, 95% CI=1.193–1.359, p<1.0×10−9), but not in Caucasians (OR= 1.024, 95% CI=0.973–1.078, p=0.358). However, metaanalysis using homozygote contrast showed an association between PADI4_94 allele 2 and RA in both Asians (OR= 2.311, 95% CI= 1.1.858–2.875, p<1.0×10−9) and Caucasians (OR=1.523, 95% CI=1.157–2.004, p=0.008). Meta-analysis also revealed an association between allele 2 of the PADI4_104 polymorphism and RA in both Asians (OR=1.547, 95% CI=1.247–1.919, p=7.1×10−6) and Caucasians (OR=1.096, 95% CI=1.025–1.172, p=0.008). Finally, meta-analysis showed an association between allele 2 of the PADI4_92 polymorphism and RA in Asians (OR= 1.263, 95% CI=1.153–1.384, p=5.8×10−8), but not in Caucasians (OR=1.123, 95% CI=0.980–1.287, p=0.095). Meta-analysis indicated no association between allele 2 of either the PADI4_90 or PADI4_89 polymorphisms and RA in Asians. This meta-analysis revealed that the PADI4_94 and PADI_104 polymorphisms are associated with susceptibility to RA in Asians and Caucasians, and that the PADI4_92 polymorphism is associated with susceptibility to RA in Asians, but not in Caucasians.

AB - The objective of the study was to determine by meta-analysis whether polymorphisms of the gene encoding peptidylarginine deiminase 4 (PADI4) are associated with susceptibility to rheumatoid arthritis (RA). A literature review was conducted to identify data sets that described analyses of genetic association between PADI4 polymorphisms and RA. Data sets were collated and a meta-analysis was performed, with a specific focus on associations within Caucasian and Asian populations. A total of 15,947 RA cases and 22,696 controls that were taken from 28 studies in 24 papers were included in this study. Meta-analysis showed a significant association between allele 2 of the PADI4_94 polymorphism and RA in the overall population (odds ratio [OR]= 1.155, 95% confidence interval [CI]=1.069–1.249, p=2.7× 10−5). Stratification by ethnicity revealed an association between PADI4_94 allele 2 and RA in Asians (OR=1.273, 95% CI=1.193–1.359, p<1.0×10−9), but not in Caucasians (OR= 1.024, 95% CI=0.973–1.078, p=0.358). However, metaanalysis using homozygote contrast showed an association between PADI4_94 allele 2 and RA in both Asians (OR= 2.311, 95% CI= 1.1.858–2.875, p<1.0×10−9) and Caucasians (OR=1.523, 95% CI=1.157–2.004, p=0.008). Meta-analysis also revealed an association between allele 2 of the PADI4_104 polymorphism and RA in both Asians (OR=1.547, 95% CI=1.247–1.919, p=7.1×10−6) and Caucasians (OR=1.096, 95% CI=1.025–1.172, p=0.008). Finally, meta-analysis showed an association between allele 2 of the PADI4_92 polymorphism and RA in Asians (OR= 1.263, 95% CI=1.153–1.384, p=5.8×10−8), but not in Caucasians (OR=1.123, 95% CI=0.980–1.287, p=0.095). Meta-analysis indicated no association between allele 2 of either the PADI4_90 or PADI4_89 polymorphisms and RA in Asians. This meta-analysis revealed that the PADI4_94 and PADI_104 polymorphisms are associated with susceptibility to RA in Asians and Caucasians, and that the PADI4_92 polymorphism is associated with susceptibility to RA in Asians, but not in Caucasians.

KW - Meta-analysis

KW - PADI4

KW - Polymorphism

KW - Rheumatoid arthritis

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JO - Clinical Rheumatology

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ER -

Association between susceptibility to rheumatoid arthritis and PADI4 polymorphisms: A meta-analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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