Association between the SUMO4 M55V (A163G) polymorphism and susceptibility to type 1 diabetes: A meta-analysis

Objective: The aim of this study was to determine whether the SUMO4 M55V (A163G) polymorphism confers susceptibility to type 1 diabetes (T1D). Methods: A meta-analysis was conducted on the association between the SUMO4 M55V polymorphism and T1D using; (1) allelic contrast (G vs. A), and the (2) recessive (GG vs. GA+AA), (3) dominant (GG+GA vs. AA), and (4) additive models (GG vs. AA). Results: Thirteen separate studies were considered in the meta-analysis, which in total included 5915 patients and 6660 controls, and five European and eight Asian sample populations. Europeans had a higher prevalence of the G allele than Asians (50.4% vs. 30.2%). Meta-analysis of the SUMO4 M55V polymorphism showed an association between T1D and the SUMO4 G allele in all study subjects (OR=1.236, 95% CI=1.112-1.373, p=7.9×10^-6), and stratification by ethnicity indicated a highly significant association between the SUMO4 G allele and T1D in Asians (OR=1.303, 95% CI=1.169-1.452, p=1.78×10^-7) and a marginal association with T1D in Europeans (OR=1.177, 95% CI=1.000-1.386, p=0.050). Furthermore, significant associations were found between the SUMO4 M55V polymorphism and T1D and all study subjects, Europeans, and Asians using the dominant model (OR=1.239, 95% CI=1.144-1.342, p=1.4×10^-8; OR=1.156, 95% CI=1.051-1.271, p=0.003; OR=1.461, 95% CI=1.262-1.691, p=3.8×10^-8, respectively). Conclusions: This meta-analysis indicates that the SUMO4 M55V polymorphism confers susceptibility to T1D in Asians and Europeans.