TY - JOUR
T1 - Association between β2 adrenoceptor polymorphisms and atopy/serum IgE in asthmatic patients
AU - Sin Hyung Lee, Hyung Lee
AU - Jae Jeong Shim, Jeong Shim
AU - Yong Koo Kang, Koo Kang
AU - Hye Cheol Jeong, Cheol Jeong
AU - Kyung Kyu Kim, Kyu Kim
AU - Young Hwan Kwon, Hwan Kwon
AU - Je Hyeong Kim, Hyeong Kim
AU - Sung Yong Lee, Yong Lee
AU - So Ra Lee, Ra Lee
AU - Sang Youb Lee, Youb Lee
AU - Jae Youn Cho, Youn Cho
AU - Kwang Ho In, Ho In
AU - Se Hwa Yoo, Hwa Yoo
AU - Kyung Ho Kang, Ho Kang
PY - 1999
Y1 - 1999
N2 - Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.
AB - Background: The β2 adrenergic receptor (β2 AR) polymorphisms occurring at amino acid position 16 (Arg to Gly), 27 (Gln to Glu), 34 (Val to Met), and 164 (Thr to Ile) are known to be functionally relevant and also disease-modifying in subjects with asthma. However the contribution of these polymorphisms to the development of the asthmatic phenotype or other markers for allergic disease remains to be established. Methods: 109 patients with bronchial asthma and 42 healthy person were included. Serum total IgE, allergen specific IgE, and skin prick test were performed to all of the subjects. β2 AR polymorphisms were checked by mutated allele specific amplification (MASA) method. Results: The results were as follows. The frequencies of β2 AR polymorphisms in asthmatic patients and healthy person were not statistically different(p>0.05). There was no association between β2 AR polymorphisms of amino acid position 16, 27, 34 and the existence of atopy among asthmatic patients(p>0.05). Between asthmatic patients with or without elevated IgE level and ̄2 AR polymorphisms of amino acid position 16, 27, 34, there was no statistically significant association(p> 0.05). Conclusion : There was no difference in frequency of the β2 AR polymorphism between asthmatic patients and healthy person. In the bronchial asthma, association of β2 AR polymorphism and atopy/serum total IgE was not found.
KW - Asthma
KW - Atopy
KW - Beta-2 adrenergic receptor
KW - IgE
KW - Polymorphism
UR - http://www.scopus.com/inward/record.url?scp=0032877106&partnerID=8YFLogxK
U2 - 10.4046/trd.1999.46.6.826
DO - 10.4046/trd.1999.46.6.826
M3 - Article
AN - SCOPUS:0032877106
SN - 0378-0066
VL - 46
SP - 826
EP - 835
JO - Tuberculosis and Respiratory Diseases
JF - Tuberculosis and Respiratory Diseases
IS - 6
ER -
