Association of G-protein β3 subunit C825T polymorphism with seasonal variations in mood and behavior

Yoon Ju Nam, Chul Hyun Cho, Leen Kim, Heon Jeong Lee

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Objective Seasonal affective disorder and seasonal changes in mood and behavior are associated with several genes that regulate circadian rhythms. In this study, we investigated the relationship between the C825T polymorphism of the G-protein β3 subunit and seasonal variations in mood and behavior in a young healthy Korean population. Methods A total of 507 young Korean participants were recruited through a newspaper advertisement, and their seasonality was evaluated by the Korean version of the Seasonal Pattern Assessment Questionnaire to assess the global seasonality score (GSS). We analyzed the CC, CT, and TT genotypes and their association with the GSS score and subscales. Results T allele carriers of the GNB3 C825T polymorphism were more likely to score higher on body weight and GSS. In the female group, the T allele carriers obtained significantly high total GSS and its subscale scores for mood, body weight, energy level, and appetite; however, differences in genotypes and allele carriers were also observed in the male sparticipants. Conclusion These results suggested that GNB3 C825T polymorphism plays a role inlles.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalPsychiatry Investigation
Issue number2
Publication statusPublished - 2018 Feb

Bibliographical note

Publisher Copyright:
© 2018 Korean Neuropsychiatric Association.


  • GNB3
  • Genetic association
  • Seasonal affective disorder
  • Seasonality

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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