Association of plasma adipokines with chronic obstructive pulmonary disease severity and progression

Yeon Mok Oh, Byeong Ho Jeong, Sook Young Woo, Su Young Kim, Hojoong Kim, Ji Hyun Lee, Seong Yong Lim, Chin Kook Rhee, Kwang Ha Yoo, Jin Hwa Lee, Hyoung Kyu Yoon, Don D. Sin, Sang Do Lee, Eun Kyung Kim, Hye Yun Park, Tae Hyung Kim, Tae Rim Shin, Sang Yeub Lee, Ho Il Yoon, Seung Soo SheenJoo Hun Park, Yong Bum Park, Changhwan Kim, Yong Il Hwang, Young Sam Kim, Ji Ye Jung, Yoon Ki Hong, Seung Won Ra, Joon Beom Seo, Sang Min Lee, In A. Jeong, Chang Hoon Lee, Sei Won Lee, Jae Seung Lee, Jin Won Huh, Ji Yong Moon, Hye Kyeong Park, Jin Woo Kim, Woo Jin Kim, Kang Hyeon Choi, Joo Ock Na, Doh Hyung Kim, Hye Sook Choi, Kwang Ha Lee, Myung Jae Park, Sung Soon Lee

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Rationale: Two adipokines, leptin and adiponectin, regulate metabolic and inflammatory systems reciprocally. The role of adiponectin in chronic obstructive pulmonary disease (COPD) has been studied. However, there are few data evaluating the relationship of plasma leptin with COPD severity or progression. Objectives: The objective of this study was to evaluate the relationship of leptin, adiponectin, and the leptin/adiponectin ratio with COPD severity and progression according to COPD phenotypes. Methods: Plasma leptin and adiponectin levels were measured in 196 subjects with COPD selected from the Korean Obstructive Lung Disease cohort. Using a linear regression model and mixed linear regression, we determined the relationship of plasma leptin and adiponectin levels and the leptin/adiponectin ratio to COPD severity and progression over 3 years. Measurements and Main Results: The concentration of adiponectin in plasma positively correlated with percent emphysema on initial computed tomography (CT) (adjusted P = 0.022), whereas plasma leptin concentrations and the leptin/adiponectin ratio exhibited a significant inverse correlation with initial FEV1 (adjusted P = 0.013 for leptin and adjusted P = 0.041 for leptin/adiponectin ratio). Increased plasma leptin and leptin/adiponectin ratiowere significantly associated with change in percent emphysema over 3 years (adjusted P = 0.037 for leptin and adjusted P = 0.029 for leptin/adiponectin ratio), whereas none of the adipokines demonstrated an association with FEV1 decline over the 3-year period. Conclusions: Plasma adiponectin and leptin vary according to COPD phenotypes. Plasma leptin and the leptin/adiponectin ratio, but not adiponectin, were significantly associated with changes in CT-assessed emphysema, suggesting a potential role as a biomarker in emphysema progression in patients with COPD.

Original languageEnglish
Pages (from-to)1005-1012
Number of pages8
JournalAnnals of the American Thoracic Society
Issue number7
Publication statusPublished - 2015 Jul 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
Copyright © 2015 by the American Thoracic Society.


  • Adiponectin
  • Chronic obstructive pulmonary disease
  • Emphysema
  • Leptin

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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