Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults

Eun Roh; Soon Young Hwang; Eyun Song; Min Jeong Park; Hye Jin Yoo; Sei Hyun Baik; Miji Kim; Chang Won Won; Kyung Mook Choi

doi:10.1038/s41598-022-19706-3

Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults

Eun Roh, Soon Young Hwang, Eyun Song, Min Jeong Park, Hye Jin Yoo, Sei Hyun Baik, Miji Kim, Chang Won Won, Kyung Mook Choi

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Brain-derived neurotrophic factor (BDNF), an exercise-induced neurotrophin, is an important factor in memory consolidation and cognitive function. This study evaluates the association between plasma BDNF levels and frailty in community-dwelling older adults. Plasma BDNF levels were analyzed in a total of 302 individuals aged 70–84 years from the Korean Frailty and Aging Cohort Study. There were 30 (9.9%) participants with frailty. They were older and had a higher prevalence of dementia and depression than those without frailty. There were no differences in the proportion of male sex between the frail and non-frail groups. Plasma BDNF levels were significantly lower in participants with frailty than in those without frailty. The presence of frailty was significantly associated with plasma BDNF levels (odds ratio 0.508, 95% confidence interval 0.304–0.849) as well as age, hemoglobin, and the presence of dementia, and depression. After adjustment for confounding factors, the significant association between plasma BDNF and frailty was maintained (0.495, 0.281–0.874). This association remained consistent after exclusion of individuals with dementia, depression, stroke, diabetes, and osteoporosis. Plasma BDNF levels were significantly associated with frailty in community-dwelling older adults. Our study may suggest the possible role of BDNF as a novel biomarker of frailty.

Original language	English
Article number	18605
Journal	Scientific reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-19706-3
Publication status	Published - 2022 Dec
Externally published	Yes

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General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41598-022-19706-3

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@article{968e48398a4143c6ae99c3415cac849a,

title = "Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults",

abstract = "Brain-derived neurotrophic factor (BDNF), an exercise-induced neurotrophin, is an important factor in memory consolidation and cognitive function. This study evaluates the association between plasma BDNF levels and frailty in community-dwelling older adults. Plasma BDNF levels were analyzed in a total of 302 individuals aged 70–84 years from the Korean Frailty and Aging Cohort Study. There were 30 (9.9%) participants with frailty. They were older and had a higher prevalence of dementia and depression than those without frailty. There were no differences in the proportion of male sex between the frail and non-frail groups. Plasma BDNF levels were significantly lower in participants with frailty than in those without frailty. The presence of frailty was significantly associated with plasma BDNF levels (odds ratio 0.508, 95% confidence interval 0.304–0.849) as well as age, hemoglobin, and the presence of dementia, and depression. After adjustment for confounding factors, the significant association between plasma BDNF and frailty was maintained (0.495, 0.281–0.874). This association remained consistent after exclusion of individuals with dementia, depression, stroke, diabetes, and osteoporosis. Plasma BDNF levels were significantly associated with frailty in community-dwelling older adults. Our study may suggest the possible role of BDNF as a novel biomarker of frailty.",

author = "Eun Roh and Hwang, {Soon Young} and Eyun Song and Park, {Min Jeong} and Yoo, {Hye Jin} and Baik, {Sei Hyun} and Miji Kim and Won, {Chang Won} and Choi, {Kyung Mook}",

note = "Funding Information: This research was supported by a grant from the Korea Health Technology R & D Project through the Korean Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health &; Welfare, Republic of Korea (Grant number: HI15C3153), and the Research Program funded by the National Institute of Health, Korea Disease Control and Prevention Agency (2021-ER0605-00). This work was also supported by Korea University Guro Hospital (Korea Research-Driven Hospital) and grant funded by Korea University Medicine (K2210431) and a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education of Korea (Grant number: 2020R1I1A1A01070499). The funders had no role in the study's design, collection, analysis, or interpretation of the data or the preparation, review, or approval of the manuscript. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41598-022-19706-3",

language = "English",

volume = "12",

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T1 - Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults

AU - Roh, Eun

AU - Hwang, Soon Young

AU - Song, Eyun

AU - Park, Min Jeong

AU - Yoo, Hye Jin

AU - Baik, Sei Hyun

AU - Kim, Miji

AU - Won, Chang Won

AU - Choi, Kyung Mook

N1 - Funding Information: This research was supported by a grant from the Korea Health Technology R & D Project through the Korean Health Industry Development Institute (KHIDI), which is funded by the Ministry of Health &; Welfare, Republic of Korea (Grant number: HI15C3153), and the Research Program funded by the National Institute of Health, Korea Disease Control and Prevention Agency (2021-ER0605-00). This work was also supported by Korea University Guro Hospital (Korea Research-Driven Hospital) and grant funded by Korea University Medicine (K2210431) and a grant from the National Research Foundation of Korea (NRF) funded by the Ministry of Education of Korea (Grant number: 2020R1I1A1A01070499). The funders had no role in the study's design, collection, analysis, or interpretation of the data or the preparation, review, or approval of the manuscript. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Brain-derived neurotrophic factor (BDNF), an exercise-induced neurotrophin, is an important factor in memory consolidation and cognitive function. This study evaluates the association between plasma BDNF levels and frailty in community-dwelling older adults. Plasma BDNF levels were analyzed in a total of 302 individuals aged 70–84 years from the Korean Frailty and Aging Cohort Study. There were 30 (9.9%) participants with frailty. They were older and had a higher prevalence of dementia and depression than those without frailty. There were no differences in the proportion of male sex between the frail and non-frail groups. Plasma BDNF levels were significantly lower in participants with frailty than in those without frailty. The presence of frailty was significantly associated with plasma BDNF levels (odds ratio 0.508, 95% confidence interval 0.304–0.849) as well as age, hemoglobin, and the presence of dementia, and depression. After adjustment for confounding factors, the significant association between plasma BDNF and frailty was maintained (0.495, 0.281–0.874). This association remained consistent after exclusion of individuals with dementia, depression, stroke, diabetes, and osteoporosis. Plasma BDNF levels were significantly associated with frailty in community-dwelling older adults. Our study may suggest the possible role of BDNF as a novel biomarker of frailty.

AB - Brain-derived neurotrophic factor (BDNF), an exercise-induced neurotrophin, is an important factor in memory consolidation and cognitive function. This study evaluates the association between plasma BDNF levels and frailty in community-dwelling older adults. Plasma BDNF levels were analyzed in a total of 302 individuals aged 70–84 years from the Korean Frailty and Aging Cohort Study. There were 30 (9.9%) participants with frailty. They were older and had a higher prevalence of dementia and depression than those without frailty. There were no differences in the proportion of male sex between the frail and non-frail groups. Plasma BDNF levels were significantly lower in participants with frailty than in those without frailty. The presence of frailty was significantly associated with plasma BDNF levels (odds ratio 0.508, 95% confidence interval 0.304–0.849) as well as age, hemoglobin, and the presence of dementia, and depression. After adjustment for confounding factors, the significant association between plasma BDNF and frailty was maintained (0.495, 0.281–0.874). This association remained consistent after exclusion of individuals with dementia, depression, stroke, diabetes, and osteoporosis. Plasma BDNF levels were significantly associated with frailty in community-dwelling older adults. Our study may suggest the possible role of BDNF as a novel biomarker of frailty.

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DO - 10.1038/s41598-022-19706-3

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SN - 2045-2322

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JO - Scientific reports

JF - Scientific reports

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ER -

Association of plasma brain-derived neurotrophic factor levels and frailty in community-dwelling older adults

Abstract

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UN SDGs

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