Association of serum retinol binding protein 4 with adiposity and pubertal development in Korean children and adolescents

Young Jun Rhie, Byung Min Choi, So Hee Eun, Chang Sung Son, Sang Hee Park, Kee Hyoung Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Retinol binding protein 4 (RBP4) has been postulated to provide a new link between obesity and insulin resistance. We aimed to assess the relationship between serum RBP4 and insulin resistance by investigating serum RBP4 levels in children and adolescents according to degree of obesity and pubertal stage. A total of 103 (30 lean, 39 overweight, 34 obese) were evaluated for serum RBP4, adiponectin, insulin, glucose and lipid profiles. RBP4 levels of obese and overweight groups were higher than those of lean group. RBP4 level was higher in pubertal group than in prepubertal group. RBP4 was positively correlated with age, height, weight, body mass index (BMI), abdominal circumference, systolic blood pressure, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), total cholesterol and triglyceride, and inversely with adiponectin. In the multiple linear regression analysis, RBP4 was found to be independently associated with pubertal stage, BMI and triglyceride but not with HOMA-IR. In conclusion, serum RBP4 level is related with degree of adiposity and pubertal development. The association of RBP4 with insulin resistance is supposed to be secondary to the relation between RBP4 and adipose tissue in children and adolescents.

Original languageEnglish
Pages (from-to)797-802
Number of pages6
JournalJournal of Korean medical science
Issue number6
Publication statusPublished - 2011 Jun
Externally publishedYes


  • Adipose tissue
  • Childhood obesity
  • Human
  • Insulin resistance
  • RBP4 protein

ASJC Scopus subject areas

  • General Medicine


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