Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder

Jin Myoung Seok; Wanzee Cho; Doo Hwan Son; Jong Hwa Shin; Eun Bin Cho; Sung Tae Kim; Byoung Joon Kim; Joon Kyung Seong; Ju Hong Min

doi:10.1038/s41598-022-05531-1

Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder

Jin Myoung Seok, Wanzee Cho, Doo Hwan Son, Jong Hwa Shin, Eun Bin Cho, Sung Tae Kim, Byoung Joon Kim, Joon Kyung Seong, Ju Hong Min

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Abstract

Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD.

Original language	English
Article number	1579
Journal	Scientific reports
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41598-022-05531-1
Publication status	Published - 2022 Dec

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) (No. 2016R1D1A1B03934476) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2019R1A2C109021211).

Funding Information:
J.H.M. is funded by and has received research support from the National Research Foundation of Korea and SMC Research and Development Grant. She has lectured, consulted, and received honoraria from Bayer Scher-ing Pharma, Merk Serono, Biogen Idec, Sanofi Genzyme, UCB, Samsung Bioepis and Roche. J.M.S. reports no relevant disclosures. W.C. reports no relevant disclosures. D.H.S. reports no relevant disclosures. J.H.S. reports no relevant disclosures. E.B.C reports no relevant disclosures. S.T.K. reports no relevant disclosures. B.J.K. reports no relevant disclosures. J.K.S. reports no relevant disclosures.

Publisher Copyright:
© 2022, The Author(s).

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@article{0fdda1ef10e24157ba33f09ddcd2f6b7,

title = "Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder",

abstract = "Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD.",

author = "Seok, {Jin Myoung} and Wanzee Cho and Son, {Doo Hwan} and Shin, {Jong Hwa} and Cho, {Eun Bin} and Kim, {Sung Tae} and Kim, {Byoung Joon} and Seong, {Joon Kyung} and Min, {Ju Hong}",

note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) (No. 2016R1D1A1B03934476) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2019R1A2C109021211). Funding Information: J.H.M. is funded by and has received research support from the National Research Foundation of Korea and SMC Research and Development Grant. She has lectured, consulted, and received honoraria from Bayer Scher-ing Pharma, Merk Serono, Biogen Idec, Sanofi Genzyme, UCB, Samsung Bioepis and Roche. J.M.S. reports no relevant disclosures. W.C. reports no relevant disclosures. D.H.S. reports no relevant disclosures. J.H.S. reports no relevant disclosures. E.B.C reports no relevant disclosures. S.T.K. reports no relevant disclosures. B.J.K. reports no relevant disclosures. J.K.S. reports no relevant disclosures. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

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doi = "10.1038/s41598-022-05531-1",

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AU - Seok, Jin Myoung

AU - Cho, Wanzee

AU - Son, Doo Hwan

AU - Shin, Jong Hwa

AU - Cho, Eun Bin

AU - Kim, Sung Tae

AU - Kim, Byoung Joon

AU - Seong, Joon Kyung

AU - Min, Ju Hong

N1 - Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) (No. 2016R1D1A1B03934476) and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. 2019R1A2C109021211). Funding Information: J.H.M. is funded by and has received research support from the National Research Foundation of Korea and SMC Research and Development Grant. She has lectured, consulted, and received honoraria from Bayer Scher-ing Pharma, Merk Serono, Biogen Idec, Sanofi Genzyme, UCB, Samsung Bioepis and Roche. J.M.S. reports no relevant disclosures. W.C. reports no relevant disclosures. D.H.S. reports no relevant disclosures. J.H.S. reports no relevant disclosures. E.B.C reports no relevant disclosures. S.T.K. reports no relevant disclosures. B.J.K. reports no relevant disclosures. J.K.S. reports no relevant disclosures. Publisher Copyright: © 2022, The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD.

AB - Although fatigue is a major symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), the underlying mechanism remains unclear. We explored the relationship between subcortical structures and fatigue severity to identify neural substrates of fatigue in NMOSD. Clinical characteristics with brain magnetic resonance imaging were evaluated in forty patients with NMOSD. Fatigue was assessed using the Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-fatigue) questionnaire (a higher score indicates less fatigue). We assessed the correlation between subcortical structures and fatigue severity using surface-based shape analysis. Most of the enrolled patients showed fatigue (72.5%; mean FACIT-fatigue score, 34.8 ± 10.8). The FACIT-fatigue score was negatively correlated with Expanded Disability Status Scale and Beck Depression Inventory scores (r = − 0.382, p = 0.016; r = − 0.578, p < 0.001). We observed that the right thalamus was the only extracted region for various threshold experiments. Further, patients with lower FACIT-fatigue scores (more fatigue) had decreased local shape volume in the right thalamus. Fatigue is common in patients with NMOSD, and atrophy in the right thalamus is strongly correlated with fatigue severity. The local shape volume of the right thalamus might serve as a biomarker of fatigue in NMOSD.

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DO - 10.1038/s41598-022-05531-1

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Association of subcortical structural shapes with fatigue in neuromyelitis optica spectrum disorder

Abstract

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