Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011

Jung A. Kim, Soon Young Hwang, Ji Hee Yu, Eun Roh, So hyeon Hong, You Bin Lee, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Nan Hee Kim, Sin Gon Kim, Sei-Hyun Baik, Kyung Mook Choi

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13 Citations (Scopus)


The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 years from the Korea National Health and Nutrition Examination Survey between 2008 and 2011. The TyG index was calculated as ln[triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Dual-energy X-ray absorptiometry was used to measure appendicular lean mass (ALM). Low muscle mass was defined an ALM/weight of 2 standard deviations (SD) below of young participants. The overall prevalence of low muscle mass was 4.7%. The prevalence of low muscle mass increased linearly with the quartiles of the TyG index, 2.5%, 4.2%, 5.6%, and 6.7% in Q1–Q4, respectively. The TyG index was negatively associated with ALM/weight both in men (r = − 0.302) and women (r = − 0.230). The odds ratio (OR) for low muscle mass was 2.08 in the highest quartile compared to the lowest quartile. High TyG index was associated with an increased risk of low muscle mass (OR for 1SD increase: 1.13). Increased TyG index was associated with the risk of low muscle mass independent of confounding factors.

Original languageEnglish
Article number450
JournalScientific reports
Issue number1
Publication statusPublished - 2021 Dec

Bibliographical note

Funding Information:
K.M.C. has grant from the Korea University Research Fund (K2020461).

Publisher Copyright:
© 2021, The Author(s).

ASJC Scopus subject areas

  • General


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