Association study between antipsychotic-induced restless legs syndrome and polymorphisms of monoamine oxidase genes in schizophrenia

Seung Gul Kang, Young Min Park, Jung Eun Choi, Se Won Lim, Heon Jeong Lee, Seung Hwan Lee, Yong Ku Kim, Seung Hyun Kim, Sung Nam Cho, Leen Kim

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Objective: This study aimed to investigate whether the monoamine oxidase (MAO) A and B genes are associated with antipsychotic-induced restless legs syndrome (RLS) in schizophrenia. Methods: We assessed antipsychotic-induced RLS symptoms in 190 Korean schizophrenic patients and divided the subjects into two groups: those with RLS symptoms (n = 96) and those without RLS symptoms (n = 94). Genotyping was performed for the variable number of tandem repeat (VNTR) polymorphism of the MAOA gene and A644G polymorphism of the MAOB gene. Results: There was no significant difference in the genotype and allele frequencies of all polymorphisms investigated between these two groups. However, the result of global haplotype analysis showed a significant difference in haplotype frequencies between male subjects with and without RLS symptoms (p = 0.013). The interaction between two polymorphisms had a significant effect on the RLS scores of both male (p = 0.047) and female (p = 0.028) patients. Conclusions: These data do not suggest that the MAOA gene VNTR and MAOB gene A644G polymorphisms are associated with antipsychotic-induced RLS symptoms in schizophrenia. However, we found that the haplotype frequencies differed between the male schizophrenic patients with and without RLS symptom and the interaction between the two polymorphisms had a significant influence on the RLS scores of patients with schizophrenia.

Original languageEnglish
Pages (from-to)397-403
Number of pages7
JournalHuman Psychopharmacology
Issue number5
Publication statusPublished - 2010 Jul


  • Antipsychotics
  • Gene-gene interaction
  • Monoamine A and B genes
  • Polymorphism
  • Restless legs syndrome
  • Schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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