Associations between vascular endothelial growth factor gene polymorphisms and pre-eclampsia susceptibility: A meta-analysis

Objective: The aim of this study was to assess whether vascular endothelial growth factor (VEGF) polymorphisms are associated with susceptibility to pre-eclampsia. Methods: A meta-analysis was conducted on the associations between the-634.C/G, +936.C/T,-1154.A/G, and-2578.A/C polymorphisms of VEGF and pre-eclampsia. Results: Ten studies involving 2068 subjects (pre-eclampsia, 950; controls, 1118) were included in the meta-analysis. The meta-analysis revealed an association between pre-eclampsia and the VEGF-634.C allele in overall group (OR.=.1.351, 95% CI.=.1.105-1.651, p.=.0.003) and in European group (OR.=.1.427, 95% CI.=.1.139-1.787, p.=.0.002). The meta-analysis revealed an association between pre-eclampsia and the VEGF-936.T allele in Asians, but not in Europeans (OR.=.1.555, 95% CI.=.1.232-1.961, p.=.1.9.×.10^-5; OR.=.1.587, 95% CI.=.0.933-2.699, p.=.0.088). However, the meta-analysis revealed no association between pre-eclampsia and the VEGF-1154.A/G and 2578.A/C polymorphisms Conclusions: This meta-analysis suggested that the VEGF-634.C/G polymorphism is associated with susceptibility to pre-eclampsia in Europeans and that the VEGF-634.C/G polymorphism is associated with pre-eclampsia in Asians.