TY - JOUR
T1 - Associations between vitamin D receptor polymorphisms and susceptibility to rheumatoid arthritis and systemic lupus erythematosus
T2 - A meta-analysis
AU - Lee, Young Ho
AU - Bae, Sang Cheol
AU - Choi, Sung Jae
AU - Ji, Jong Dae
AU - Song, Gwan Gyu
N1 - Funding Information:
Acknowledgments This study was supported by grants from the Korean Healthcare Technology R&D Project, Ministry of Health, Welfare, and Family Affairs, Republic of Korea (A084794, A080588).
PY - 2011/8
Y1 - 2011/8
N2 - The aim of this study was to determine whether the vitamin D receptor (VDR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE). A meta-analysis was conducted on the associations between the BsmI, TaqI, FokI, and ApaI polymorphisms of VDR and RA or SLE using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) additive model. A total of ten studies, six RA and four SLE studies, were considered in the meta-analysis. Meta-analysis of the VDR BsmI and TaqI polymorphisms showed no association between RA in all subjects, or in European or Asian subjects. In contrast, meta-analysis of the F allele, the FF genotype, and the FF vs. the ff genotype of the FokI polymorphism showed significant associations with RA in Europeans. The overall OR of the association between the F allele and RA was 1.502 (95% CI = 1.158-1.949, P = 0.002). Meta-analysis of the B allele, BB + Bb genotype, and BB genotype (additive model) of the BsmI polymorphism showed significant associations with SLE and LN in Asians. The overall ORs of the associations between the B allele and SLE and LN were 3.584 (95% CI = 1.407-9.130, P = 0.007) and 3.652 (95% CI = 1.347-9.902, P = 0.011). This meta-analysis demonstrates that the VDR FokI polymorphism may confer susceptibility to RA in Europeans. Furthermore, associations were found between the VDR BsmI polymorphism and susceptibilities to SLE and LN in Asians.
AB - The aim of this study was to determine whether the vitamin D receptor (VDR) polymorphisms confer susceptibility to rheumatoid arthritis (RA) and systemic lupus erythematous (SLE). A meta-analysis was conducted on the associations between the BsmI, TaqI, FokI, and ApaI polymorphisms of VDR and RA or SLE using: (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) additive model. A total of ten studies, six RA and four SLE studies, were considered in the meta-analysis. Meta-analysis of the VDR BsmI and TaqI polymorphisms showed no association between RA in all subjects, or in European or Asian subjects. In contrast, meta-analysis of the F allele, the FF genotype, and the FF vs. the ff genotype of the FokI polymorphism showed significant associations with RA in Europeans. The overall OR of the association between the F allele and RA was 1.502 (95% CI = 1.158-1.949, P = 0.002). Meta-analysis of the B allele, BB + Bb genotype, and BB genotype (additive model) of the BsmI polymorphism showed significant associations with SLE and LN in Asians. The overall ORs of the associations between the B allele and SLE and LN were 3.584 (95% CI = 1.407-9.130, P = 0.007) and 3.652 (95% CI = 1.347-9.902, P = 0.011). This meta-analysis demonstrates that the VDR FokI polymorphism may confer susceptibility to RA in Europeans. Furthermore, associations were found between the VDR BsmI polymorphism and susceptibilities to SLE and LN in Asians.
KW - Meta-analysis
KW - Polymorphism
KW - Rheumatoid arthritis
KW - Systemic lupus erythematosus
KW - Vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=80052462502&partnerID=8YFLogxK
U2 - 10.1007/s11033-010-0477-4
DO - 10.1007/s11033-010-0477-4
M3 - Article
C2 - 21110115
AN - SCOPUS:80052462502
SN - 0301-4851
VL - 38
SP - 3643
EP - 3651
JO - Molecular biology reports
JF - Molecular biology reports
IS - 6
ER -