Associations of exposure to phthalates and environmental phenols with gynecological disorders

Jangwoo Lee; Yunsun Jeong; Sori Mok; Kyungho Choi; Jeongim Park; Hyo Bang Moon; Gyuyeon Choi; Hai Joong Kim; Su Young Kim; Soo Ran Choi; Sungkyoon Kim

doi:10.1016/j.reprotox.2020.04.076

Associations of exposure to phthalates and environmental phenols with gynecological disorders

Jangwoo Lee, Yunsun Jeong, Sori Mok, Kyungho Choi, Jeongim Park, Hyo Bang Moon, Gyuyeon Choi, Hai Joong Kim, Su Young Kim, Soo Ran Choi, Sungkyoon Kim

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Phthalates and environmental phenols might be associated with some benign diseases that have been found to be hormone-sensitive. Current knowledge on adverse effects of these chemicals among reproductive women is limited and often controversial. Therefore, the purpose of this study was to investigate the association between the urinary concentration of phthalates and environmental phenols and gynecological disorders from 512 women of reproductive age. The association between chemical concentration and disease in the control and case groups was statistically determined with the questionnaire survey data and measurements using the LC–MS/MS. The results have shown that DEHP metabolites, ethyl paraben and 3,4-DHB showed significant direct associations with leiomyoma and benign ovarian tumors (p < 0.05). We found statistically significant positive relationships between exposure to chemicals (some DEHP metabolites, DHB) and prevalence of gynecologic disorders (p < 0.05). Furthermore, the ORs for leiomyoma associated with these compounds in always user for personal care products (PCPs) was higher than those of sometimes user. High levels of urinary concentrations of these compounds such as DEHP metabolites and parabens and their metabolites showed significant associations with leiomyoma and benign ovarian tumors.

Original language	English
Pages (from-to)	19-28
Number of pages	10
Journal	Reproductive Toxicology
Volume	95
DOIs	https://doi.org/10.1016/j.reprotox.2020.04.076
Publication status	Published - 2020 Aug
Externally published	Yes

Keywords

Benign diseases
Environmental phenols
Personal care products
Phthalates
Women of reproductive age

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/j.reprotox.2020.04.076

Cite this

@article{0374fb60383749efb2b1cff96259a096,

title = "Associations of exposure to phthalates and environmental phenols with gynecological disorders",

abstract = "Phthalates and environmental phenols might be associated with some benign diseases that have been found to be hormone-sensitive. Current knowledge on adverse effects of these chemicals among reproductive women is limited and often controversial. Therefore, the purpose of this study was to investigate the association between the urinary concentration of phthalates and environmental phenols and gynecological disorders from 512 women of reproductive age. The association between chemical concentration and disease in the control and case groups was statistically determined with the questionnaire survey data and measurements using the LC–MS/MS. The results have shown that DEHP metabolites, ethyl paraben and 3,4-DHB showed significant direct associations with leiomyoma and benign ovarian tumors (p < 0.05). We found statistically significant positive relationships between exposure to chemicals (some DEHP metabolites, DHB) and prevalence of gynecologic disorders (p < 0.05). Furthermore, the ORs for leiomyoma associated with these compounds in always user for personal care products (PCPs) was higher than those of sometimes user. High levels of urinary concentrations of these compounds such as DEHP metabolites and parabens and their metabolites showed significant associations with leiomyoma and benign ovarian tumors.",

keywords = "Benign diseases, Environmental phenols, Personal care products, Phthalates, Women of reproductive age",

author = "Jangwoo Lee and Yunsun Jeong and Sori Mok and Kyungho Choi and Jeongim Park and Moon, {Hyo Bang} and Gyuyeon Choi and Kim, {Hai Joong} and Kim, {Su Young} and Choi, {Soo Ran} and Sungkyoon Kim",

note = "Funding Information: This study was supported by the Korea Environmental Industry & Technology Institute (KEITI) under the Ministry of Environment of Korea ( #2015001940003 ), National Research Foundation of Korea (BK21 PLUS) , and 2016 Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning of Korea ( 2016R1A2B4015646 ). Funding Information: This study was supported by the Korea Environmental Industry & Technology Institute (KEITI) under the Ministry of Environment of Korea (#2015001940003), National Research Foundation of Korea (BK21 PLUS), and 2016 Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning of Korea (2016R1A2B4015646). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

doi = "10.1016/j.reprotox.2020.04.076",

language = "English",

volume = "95",

pages = "19--28",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Associations of exposure to phthalates and environmental phenols with gynecological disorders

AU - Lee, Jangwoo

AU - Jeong, Yunsun

AU - Mok, Sori

AU - Choi, Kyungho

AU - Park, Jeongim

AU - Moon, Hyo Bang

AU - Choi, Gyuyeon

AU - Kim, Hai Joong

AU - Kim, Su Young

AU - Choi, Soo Ran

AU - Kim, Sungkyoon

N1 - Funding Information: This study was supported by the Korea Environmental Industry & Technology Institute (KEITI) under the Ministry of Environment of Korea ( #2015001940003 ), National Research Foundation of Korea (BK21 PLUS) , and 2016 Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning of Korea ( 2016R1A2B4015646 ). Funding Information: This study was supported by the Korea Environmental Industry & Technology Institute (KEITI) under the Ministry of Environment of Korea (#2015001940003), National Research Foundation of Korea (BK21 PLUS), and 2016 Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning of Korea (2016R1A2B4015646). Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/8

Y1 - 2020/8

N2 - Phthalates and environmental phenols might be associated with some benign diseases that have been found to be hormone-sensitive. Current knowledge on adverse effects of these chemicals among reproductive women is limited and often controversial. Therefore, the purpose of this study was to investigate the association between the urinary concentration of phthalates and environmental phenols and gynecological disorders from 512 women of reproductive age. The association between chemical concentration and disease in the control and case groups was statistically determined with the questionnaire survey data and measurements using the LC–MS/MS. The results have shown that DEHP metabolites, ethyl paraben and 3,4-DHB showed significant direct associations with leiomyoma and benign ovarian tumors (p < 0.05). We found statistically significant positive relationships between exposure to chemicals (some DEHP metabolites, DHB) and prevalence of gynecologic disorders (p < 0.05). Furthermore, the ORs for leiomyoma associated with these compounds in always user for personal care products (PCPs) was higher than those of sometimes user. High levels of urinary concentrations of these compounds such as DEHP metabolites and parabens and their metabolites showed significant associations with leiomyoma and benign ovarian tumors.

AB - Phthalates and environmental phenols might be associated with some benign diseases that have been found to be hormone-sensitive. Current knowledge on adverse effects of these chemicals among reproductive women is limited and often controversial. Therefore, the purpose of this study was to investigate the association between the urinary concentration of phthalates and environmental phenols and gynecological disorders from 512 women of reproductive age. The association between chemical concentration and disease in the control and case groups was statistically determined with the questionnaire survey data and measurements using the LC–MS/MS. The results have shown that DEHP metabolites, ethyl paraben and 3,4-DHB showed significant direct associations with leiomyoma and benign ovarian tumors (p < 0.05). We found statistically significant positive relationships between exposure to chemicals (some DEHP metabolites, DHB) and prevalence of gynecologic disorders (p < 0.05). Furthermore, the ORs for leiomyoma associated with these compounds in always user for personal care products (PCPs) was higher than those of sometimes user. High levels of urinary concentrations of these compounds such as DEHP metabolites and parabens and their metabolites showed significant associations with leiomyoma and benign ovarian tumors.

KW - Benign diseases

KW - Environmental phenols

KW - Personal care products

KW - Phthalates

KW - Women of reproductive age

UR - http://www.scopus.com/inward/record.url?scp=85084566484&partnerID=8YFLogxK

U2 - 10.1016/j.reprotox.2020.04.076

DO - 10.1016/j.reprotox.2020.04.076

M3 - Article

C2 - 32360183

AN - SCOPUS:85084566484

SN - 0890-6238

VL - 95

SP - 19

EP - 28

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Associations of exposure to phthalates and environmental phenols with gynecological disorders

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this