Associations of low muscle mass and the metabolic syndrome in Caucasian and Asian middle-aged and older adults

D. Scott; M. S. Park; T. N. Kim; J. Y. Ryu; H. C. Hong; H. J. Yoo; S. H. Baik; G. Jones; Kyung Mook Choi

doi:10.1007/s12603-015-0559-z

Associations of low muscle mass and the metabolic syndrome in Caucasian and Asian middle-aged and older adults

D. Scott, M. S. Park, T. N. Kim, J. Y. Ryu, H. C. Hong, H. J. Yoo, S. H. Baik, G. Jones, Kyung Mook Choi

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Objective: Age-related declines in skeletal muscle mass may confer significant metabolic consequences for older adults. Associations of low muscle mass and metabolic syndrome (MetS) in Caucasians, and comparisons with associations observed in Asian populations, have not been reported. We examined associations of low muscle mass and metabolic syndrome (MetS) in Asian and Caucasian middle-aged and older men and women using criteria for low muscle mass. Design, Setting and Participants: Two population-based studies of Australian (Tasmanian Older Adult Cohort Study; TASOAC; N=1005) and Korean (Korean Sarcopenic Obesity Study; KSOS; N=376) community-dwelling adults, mean age 62 and 58 years, respectively. Measurements: Appendicular lean mass (aLM) determined by dual-energy X-ray absorptiometry and normalised to height squared (aLM/Ht2), weight (aLM/Wt) or body mass index (aLM/BMI). Participants in the lowest sex-specific 20% for aLM measures were defined as having low muscle mass. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Although Australians demonstrated generally unfavourable anthropometric and metabolic characteristics compared to Koreans, prevalence of MetS was similar (29.5% in Australians and 31.4% in Koreans, respectively). Low aLM/Ht2 was associated with significantly reduced likelihood of MetS in both Australians (OR: 0.30, 95% CI 0.19 - 0.46) and Koreans (OR: 0.31, 95% CI 0.16 – 0.62). Conversely, low aLM/BMI was associated with increased odds for MetS in Australians (OR: 1.78, 95% CI 1.12–2.84), but not Koreans (OR: 1.33, 95% CI = 0.67–2.64). Conclusion: Low aLM/BMI is associated with significantly increased likelihood of MetS in Australian adults, but not Koreans, suggesting potential differences in effects of low muscle mass relative to body mass on cardiometabolic health in Caucasian and Asian middle-aged and older adults. Low muscle mass relative to height is associated with reduced likelihood of MetS in both populations.

Original language	English
Pages (from-to)	248-255
Number of pages	8
Journal	Journal of Nutrition, Health and Aging
Volume	20
Issue number	3
DOIs	https://doi.org/10.1007/s12603-015-0559-z
Publication status	Published - 2016 Mar 1

Bibliographical note

Funding Information:
Funding Source: The TASOAC study was supported by the National Health and Medical Research Council of Australia; Arthritis Foundation of Australia; Tasmanian Community Fund; and University of Tasmania Institutional Research Grants Scheme. We gratefully acknowledge the efforts of the TASOAC participants and staff, particularly study coordinator Catrina Boon. KSOS was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2012006363) (K.M.C.) and by Priority Research Centers Program through the NRF funded by the Ministry of Education, Science, and Technology (2010-0020224) (T.N.K.).

Publisher Copyright:
© 2016, Serdi and Springer-Verlag France.

Keywords

Muscle mass
aging
metabolic syndrome
sarcopenia

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics
Geriatrics and Gerontology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12603-015-0559-z

Cite this

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title = "Associations of low muscle mass and the metabolic syndrome in Caucasian and Asian middle-aged and older adults",

abstract = "Objective: Age-related declines in skeletal muscle mass may confer significant metabolic consequences for older adults. Associations of low muscle mass and metabolic syndrome (MetS) in Caucasians, and comparisons with associations observed in Asian populations, have not been reported. We examined associations of low muscle mass and metabolic syndrome (MetS) in Asian and Caucasian middle-aged and older men and women using criteria for low muscle mass. Design, Setting and Participants: Two population-based studies of Australian (Tasmanian Older Adult Cohort Study; TASOAC; N=1005) and Korean (Korean Sarcopenic Obesity Study; KSOS; N=376) community-dwelling adults, mean age 62 and 58 years, respectively. Measurements: Appendicular lean mass (aLM) determined by dual-energy X-ray absorptiometry and normalised to height squared (aLM/Ht2), weight (aLM/Wt) or body mass index (aLM/BMI). Participants in the lowest sex-specific 20% for aLM measures were defined as having low muscle mass. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Although Australians demonstrated generally unfavourable anthropometric and metabolic characteristics compared to Koreans, prevalence of MetS was similar (29.5% in Australians and 31.4% in Koreans, respectively). Low aLM/Ht2 was associated with significantly reduced likelihood of MetS in both Australians (OR: 0.30, 95% CI 0.19 - 0.46) and Koreans (OR: 0.31, 95% CI 0.16 – 0.62). Conversely, low aLM/BMI was associated with increased odds for MetS in Australians (OR: 1.78, 95% CI 1.12–2.84), but not Koreans (OR: 1.33, 95% CI = 0.67–2.64). Conclusion: Low aLM/BMI is associated with significantly increased likelihood of MetS in Australian adults, but not Koreans, suggesting potential differences in effects of low muscle mass relative to body mass on cardiometabolic health in Caucasian and Asian middle-aged and older adults. Low muscle mass relative to height is associated with reduced likelihood of MetS in both populations.",

keywords = "Muscle mass, aging, metabolic syndrome, sarcopenia",

author = "D. Scott and Park, {M. S.} and Kim, {T. N.} and Ryu, {J. Y.} and Hong, {H. C.} and Yoo, {H. J.} and Baik, {S. H.} and G. Jones and Choi, {Kyung Mook}",

note = "Funding Information: Funding Source: The TASOAC study was supported by the National Health and Medical Research Council of Australia; Arthritis Foundation of Australia; Tasmanian Community Fund; and University of Tasmania Institutional Research Grants Scheme. We gratefully acknowledge the efforts of the TASOAC participants and staff, particularly study coordinator Catrina Boon. KSOS was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2012006363) (K.M.C.) and by Priority Research Centers Program through the NRF funded by the Ministry of Education, Science, and Technology (2010-0020224) (T.N.K.). Publisher Copyright: {\textcopyright} 2016, Serdi and Springer-Verlag France.",

year = "2016",

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doi = "10.1007/s12603-015-0559-z",

language = "English",

volume = "20",

pages = "248--255",

journal = "Journal of Nutrition, Health and Aging",

issn = "1279-7707",

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TY - JOUR

T1 - Associations of low muscle mass and the metabolic syndrome in Caucasian and Asian middle-aged and older adults

AU - Scott, D.

AU - Park, M. S.

AU - Kim, T. N.

AU - Ryu, J. Y.

AU - Hong, H. C.

AU - Yoo, H. J.

AU - Baik, S. H.

AU - Jones, G.

AU - Choi, Kyung Mook

N1 - Funding Information: Funding Source: The TASOAC study was supported by the National Health and Medical Research Council of Australia; Arthritis Foundation of Australia; Tasmanian Community Fund; and University of Tasmania Institutional Research Grants Scheme. We gratefully acknowledge the efforts of the TASOAC participants and staff, particularly study coordinator Catrina Boon. KSOS was supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2012006363) (K.M.C.) and by Priority Research Centers Program through the NRF funded by the Ministry of Education, Science, and Technology (2010-0020224) (T.N.K.). Publisher Copyright: © 2016, Serdi and Springer-Verlag France.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective: Age-related declines in skeletal muscle mass may confer significant metabolic consequences for older adults. Associations of low muscle mass and metabolic syndrome (MetS) in Caucasians, and comparisons with associations observed in Asian populations, have not been reported. We examined associations of low muscle mass and metabolic syndrome (MetS) in Asian and Caucasian middle-aged and older men and women using criteria for low muscle mass. Design, Setting and Participants: Two population-based studies of Australian (Tasmanian Older Adult Cohort Study; TASOAC; N=1005) and Korean (Korean Sarcopenic Obesity Study; KSOS; N=376) community-dwelling adults, mean age 62 and 58 years, respectively. Measurements: Appendicular lean mass (aLM) determined by dual-energy X-ray absorptiometry and normalised to height squared (aLM/Ht2), weight (aLM/Wt) or body mass index (aLM/BMI). Participants in the lowest sex-specific 20% for aLM measures were defined as having low muscle mass. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Although Australians demonstrated generally unfavourable anthropometric and metabolic characteristics compared to Koreans, prevalence of MetS was similar (29.5% in Australians and 31.4% in Koreans, respectively). Low aLM/Ht2 was associated with significantly reduced likelihood of MetS in both Australians (OR: 0.30, 95% CI 0.19 - 0.46) and Koreans (OR: 0.31, 95% CI 0.16 – 0.62). Conversely, low aLM/BMI was associated with increased odds for MetS in Australians (OR: 1.78, 95% CI 1.12–2.84), but not Koreans (OR: 1.33, 95% CI = 0.67–2.64). Conclusion: Low aLM/BMI is associated with significantly increased likelihood of MetS in Australian adults, but not Koreans, suggesting potential differences in effects of low muscle mass relative to body mass on cardiometabolic health in Caucasian and Asian middle-aged and older adults. Low muscle mass relative to height is associated with reduced likelihood of MetS in both populations.

AB - Objective: Age-related declines in skeletal muscle mass may confer significant metabolic consequences for older adults. Associations of low muscle mass and metabolic syndrome (MetS) in Caucasians, and comparisons with associations observed in Asian populations, have not been reported. We examined associations of low muscle mass and metabolic syndrome (MetS) in Asian and Caucasian middle-aged and older men and women using criteria for low muscle mass. Design, Setting and Participants: Two population-based studies of Australian (Tasmanian Older Adult Cohort Study; TASOAC; N=1005) and Korean (Korean Sarcopenic Obesity Study; KSOS; N=376) community-dwelling adults, mean age 62 and 58 years, respectively. Measurements: Appendicular lean mass (aLM) determined by dual-energy X-ray absorptiometry and normalised to height squared (aLM/Ht2), weight (aLM/Wt) or body mass index (aLM/BMI). Participants in the lowest sex-specific 20% for aLM measures were defined as having low muscle mass. MetS was defined according to National Cholesterol Education Program Adult Treatment Panel III criteria. Results: Although Australians demonstrated generally unfavourable anthropometric and metabolic characteristics compared to Koreans, prevalence of MetS was similar (29.5% in Australians and 31.4% in Koreans, respectively). Low aLM/Ht2 was associated with significantly reduced likelihood of MetS in both Australians (OR: 0.30, 95% CI 0.19 - 0.46) and Koreans (OR: 0.31, 95% CI 0.16 – 0.62). Conversely, low aLM/BMI was associated with increased odds for MetS in Australians (OR: 1.78, 95% CI 1.12–2.84), but not Koreans (OR: 1.33, 95% CI = 0.67–2.64). Conclusion: Low aLM/BMI is associated with significantly increased likelihood of MetS in Australian adults, but not Koreans, suggesting potential differences in effects of low muscle mass relative to body mass on cardiometabolic health in Caucasian and Asian middle-aged and older adults. Low muscle mass relative to height is associated with reduced likelihood of MetS in both populations.

KW - Muscle mass

KW - aging

KW - metabolic syndrome

KW - sarcopenia

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U2 - 10.1007/s12603-015-0559-z

DO - 10.1007/s12603-015-0559-z

M3 - Article

C2 - 26892573

AN - SCOPUS:84959566436

SN - 1279-7707

VL - 20

SP - 248

EP - 255

JO - Journal of Nutrition, Health and Aging

JF - Journal of Nutrition, Health and Aging

IS - 3

ER -

Associations of low muscle mass and the metabolic syndrome in Caucasian and Asian middle-aged and older adults

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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