TY - JOUR
T1 - Associations of obesity with lipoprotein subfractions in Japanese American, African American, and Korean men
AU - Hirooka, Nobutaka
AU - Shin, Chol
AU - Masaki, Kamal H.
AU - Edmundowicz, Daniel
AU - Choo, Jina
AU - Barinas-Mitchell, Emma J.M.
AU - Willcox, Bradley J.
AU - Sutton-Tyrrell, Kim
AU - El-Saed, Aiman
AU - Miljkovic-Gacic, Iva
AU - Ohkubo, Takayoshi
AU - Miura, Katsuyuki
AU - Ueshima, Hirotsugu
AU - Kuller, Lewis H.
AU - Sekikawa, Akira
N1 - Funding Information:
This research was supported by grants HL68200 and HL071561 from the National Institutes of Health , Korea Centers for Disease Control and Prevention (budget codes 2004-E71001-00, 205-E71001-00), as well as B 16790335 and A 13307016 , 17209023 , and 21249043 from the Japanese Ministry of Education, Culture, Sports, Science and Technology .
PY - 2013/9
Y1 - 2013/9
N2 - Background Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups. Objective This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions. Methods A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity - that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index - and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein. Conclusions VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.
AB - Background Both indices of obesity and lipoprotein subfractions contribute to coronary heart disease risk. However, associations between indices of obesity and lipoprotein subfractions remain undetermined across different ethnic groups. Objective This study aims to examine the associations of indices of obesity in Japanese Americans, African Americans, and Koreans with lipoprotein subfractions. Methods A population-based sample of 230 Japanese American, 91 African American, and 291 Korean men ages 40 to 49 was examined for indices of obesity - that is, visceral and subcutaneous adipose tissue (VAT and SAT, respectively); waist circumference; and body mass index - and for lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Multiple regression analyses were performed in each of the 3 ethnic groups to examine the associations of each index of obesity with lipoprotein. Conclusions VAT had significant positive associations with total and small low-density lipoprotein (LDL) and a significant negative association with large high-density lipoprotein (HDL) in all 3 ethnicities (p < 0.01). SAT, waist circumference, and body mass index had significant positive associations with total and small LDL in only Japanese Americans and Koreans, whereas these indices had significant inverse associations with large HDL in all ethnic groups (p < 0.01). Compared with SAT, VAT had larger R2 values in the associations with total and small LDL and large HDL in all 3 ethnic groups. VAT is significantly associated with total and small LDL and large HDL in all 3 ethnic groups. The associations of SAT, waist circumference, and body mass index with lipoprotein subfractions are weaker than the associations of VAT in all 3 ethnic groups.
UR - http://www.scopus.com/inward/record.url?scp=84884951794&partnerID=8YFLogxK
U2 - 10.1016/j.gheart.2013.07.001
DO - 10.1016/j.gheart.2013.07.001
M3 - Article
AN - SCOPUS:84884951794
SN - 2211-8160
VL - 8
SP - 273
EP - 280
JO - Global Heart
JF - Global Heart
IS - 3
ER -
