Asterias pectinifera derived collagen peptide-encapsulating elastic nanoliposomes for the cosmetic application

Seong Beom Han, Bada Won, Seung chan Yang, Dong Hwee Kim

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Asterias pectinifera, a starfish that has been known to ruin the aquaculture industry owing to its voracious appetite, has recently been identified as an eco-friendly source of non-toxic and highly water-soluble low-molecular weight collagen peptides, which promotes wound healing, bone regeneration, and skin protection. Although they have potential applications in biomedical applications, including pharmaceuticals and cosmetic products, it remains unclear how to improve the in vivo absorption of collagen peptides. Here, we present a novel method to enhance the absorption rate of collagen peptides using a lipid-based nanocarrier. We prepared an elastic nanoliposome by controlling the composition ratio of phospholipids and low-molecular weight collagen peptides. Our results indicate that low-molecular weight collagen peptides extracted from Asterias pectinifera have higher encapsulation efficiency than the collagen peptides extracted from pork and fish, which have traditionally been considered as a conventional source of collagen. Moreover, we demonstrate that the elastic nanoliposome containing the collagen peptide of Asterias pectinifera can reduce MMP-1 expression caused by ultraviolet radiation-induced photoaging. Therefore, the combination of Asterias pectinifera-derived low-molecular-weight collagen peptides and elastic nanoliposomes may be a promising formulation as an eco-friendly source of materials for anti-aging cosmetics.

Original languageEnglish
Pages (from-to)289-297
Number of pages9
JournalJournal of Industrial and Engineering Chemistry
Publication statusPublished - 2021 Jun 25

Bibliographical note

Funding Information:
This work was performed by the collaboration with Starstech Co. partly supported by the Technology Development Program (S2788590) funded by the Ministry of SMEs and Startups (MSS, Korea). The authors thank members of the Applied Mechanobiology Group (AMG) at Korea University and Stars? Tech for constructive discussion of marine biotechnology. D.K. was supported by National Research Foundation of Korea (NRF-2019R1A2C2004437) and the MSIT (Ministry of Science and ICT), Korea, under the ICT Creative Consilience program (IITP-2020-0-01819) supervised by the IITP (Institute for Information & communications Technology Planning & Evaluation). D.K. and S.H. appreciate the financial support from KU-KIST Graduate School of Converging Science and Technology Program.

Publisher Copyright:
© 2021 The Author(s)


  • Anti-aging
  • Asterias pectinifera
  • Cosmetic application
  • Elastic nanoliposome
  • Marine biotechnology
  • Starfish collagen

ASJC Scopus subject areas

  • General Chemical Engineering


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