Asymmetric nozzle inlet was suggested for particles to converge into a highly confined region. The physical properties from the nano-scaled volumetric difference at nozzle inlet were investigated using computational fluid dynamics and particle motion measurement with fluorescence beads and erythrocytes. The asymmetric nozzle structure made particles converge efficiently without clogging at nozzle inlet. It could be used as a micro/nanofluidic unit for cell based assay in a microchip such as chip-based flow cytometer.
Bibliographical noteFunding Information:
This study has been supported by grants of the Intelligent Microsystem Program (IMP) of the 21st Century Frontier R&D Program sponsored by the Korea Ministry of Science and Technology and the IMT 2000 R&D Project, Ministry of Information & Communication, Republic of Korea.
Copyright 2018 Elsevier B.V., All rights reserved.
- Asymmetric nozzle
- Flow cytometer
- Particle clogging
ASJC Scopus subject areas
- General Materials Science
- General Physics and Astronomy