Attenuated neuropathic pain in CaV3.1 null mice

Heung Sik Na; Soonwook Choi; Junesun Kim; Joonoh Park; Hee Sup Shin

Attenuated neuropathic pain in Ca_V3.1 null mice

Heung Sik Na, Soonwook Choi, Junesun Kim, Joonoh Park, Hee Sup Shin

Research output: Contribution to journal › Article › peer-review

Abstract

To assess the role of α_IG T-type Ca^2- channels in neuropathic pain After L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Ca_v3.1 (α_IG^--), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw with drawal in response to mechanical stimulation were observed in these mice. The α_IG ^-- mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of neuropathic pain, Ca^2- channels in the development of neuropathic pain, and suggest that selective modulation of α_IG subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

Original language	English
Pages (from-to)	242-246
Number of pages	5
Journal	Molecules and cells
Volume	25
Issue number	2
Publication status	Published - 2008 Apr 30

Keywords

Allodynia
Central sensitization
Hyperalgesia
Spinal nerve ligation (SNL)
T-type calcium channel

ASJC Scopus subject areas

Molecular Biology
Cell Biology

Cite this

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title = "Attenuated neuropathic pain in CaV3.1 null mice",

abstract = "To assess the role of αIG T-type Ca2- channels in neuropathic pain After L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Cav3.1 (αIG--), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw with drawal in response to mechanical stimulation were observed in these mice. The αIG -- mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of neuropathic pain, Ca2- channels in the development of neuropathic pain, and suggest that selective modulation of αIG subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.",

keywords = "Allodynia, Central sensitization, Hyperalgesia, Spinal nerve ligation (SNL), T-type calcium channel",

author = "Na, {Heung Sik} and Soonwook Choi and Junesun Kim and Joonoh Park and Shin, {Hee Sup}",

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T1 - Attenuated neuropathic pain in CaV3.1 null mice

AU - Na, Heung Sik

AU - Choi, Soonwook

AU - Kim, Junesun

AU - Park, Joonoh

AU - Shin, Hee Sup

PY - 2008/4/30

Y1 - 2008/4/30

N2 - To assess the role of αIG T-type Ca2- channels in neuropathic pain After L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Cav3.1 (αIG--), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw with drawal in response to mechanical stimulation were observed in these mice. The αIG -- mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of neuropathic pain, Ca2- channels in the development of neuropathic pain, and suggest that selective modulation of αIG subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

AB - To assess the role of αIG T-type Ca2- channels in neuropathic pain After L5 spinal nerve ligation, we examined behavioral pain susceptibility in mice lacking Cav3.1 (αIG--), the gene encoding the pore-forming units of these channels. Reduced spontaneous pain responses and an increased threshold for paw with drawal in response to mechanical stimulation were observed in these mice. The αIG -- mice also showed attenuated thermal hyperalgesia in response to both low-(IR30) and high-intensity (IR60) infrared stimulation. Our results reveal the importance of neuropathic pain, Ca2- channels in the development of neuropathic pain, and suggest that selective modulation of αIG subtype channels may provide a novel approach to the treatment of allodynia and hyperalgesia.

KW - Allodynia

KW - Central sensitization

KW - Hyperalgesia

KW - Spinal nerve ligation (SNL)

KW - T-type calcium channel

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AN - SCOPUS:44949169576

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JF - Molecules and cells

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ER -

Attenuated neuropathic pain in Ca_V3.1 null mice

Abstract

Keywords

ASJC Scopus subject areas

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