Abstract
Hippocampal subfields play important and divergent roles in both memory formation and early diagnosis of many neurological diseases, but automatic subfield segmentation is less explored due to its small size and poor image contrast. In this paper, we propose an automatic learning-based hippocampal subfields segmentation framework using multi-modality 3TMR images, including T1 MRI and restingstate fMRI (rs-fMRI). To do this, we first acquire both 3T and 7T T1 MRIs for each training subject, and then the 7T T1 MRI are linearly registered onto the 3T T1 MRI. Six hippocampal subfields are manually labeled on the aligned 7T T1 MRI, which has the 7T image contrast but sits in the 3T T1 space. Next, corresponding appearance and relationship features from both 3T T1 MRI and rs-fMRI are extracted to train a structured random forest as a multi-label classifier to conduct the segmentation. Finally, the subfield segmentation is further refined iteratively by additional context features and updated relationship features. To our knowledge, this is the first work that addresses the challenging automatic hippocampal subfields segmentation using 3T routine T1 MRI and rs-fMRI. The quantitative comparison between our results and manual ground truth demonstrates the effectiveness of our method. Besides, we also find that (a) multi-modality features significantly improved subfield segmentation performance due to the complementary information among modalities; (b) automatic segmentation results using 3T multimodality images are partially comparable to those on 7T T1 MRI.
Original language | English |
---|---|
Title of host publication | Machine Learning in Medical Imaging - 7th International Workshop, MLMI 2016 held in conjunction with MICCAI 2016, Proceedings |
Editors | Li Wang, Heung-Il Suk, Yinghuan Shi, Ehsan Adeli, Qian Wang |
Publisher | Springer Verlag |
Pages | 229-236 |
Number of pages | 8 |
ISBN (Print) | 9783319471563 |
DOIs | |
Publication status | Published - 2016 |
Event | 7th International Workshop on Machine Learning in Medical Imaging, MLMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 - Athens, Greece Duration: 2016 Oct 17 → 2016 Oct 17 |
Publication series
Name | Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) |
---|---|
Volume | 10019 LNCS |
ISSN (Print) | 0302-9743 |
ISSN (Electronic) | 1611-3349 |
Other
Other | 7th International Workshop on Machine Learning in Medical Imaging, MLMI 2016 held in conjunction with 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016 |
---|---|
Country/Territory | Greece |
City | Athens |
Period | 16/10/17 → 16/10/17 |
Bibliographical note
Publisher Copyright:© Springer International Publishing AG 2016.
ASJC Scopus subject areas
- Theoretical Computer Science
- General Computer Science