Automation control system for servo prep column of high-performance liquid chromatography based on fuzzy inference control

Oyoung Kwon, Hyung Suk Park, Seok Geun Oh, Daehie Hong

Research output: Contribution to journalReview articlepeer-review


This paper describes a control system for the servo prep column of High-Performance Liquid Chromatography (HPLC) based on fuzzy inference control. The key technology in pharmaceutical and biotechnology industries is refining performance and efforts to reduce costs by purifying target compounds with high purity at high yield while maintaining target compounds, is the major focus of new product development. Among the many refinement techniques, the most popular chromatographic methods require a column that can charge the resin with excellent performance and reproducibility. However, the present HPLC prep column has a hydraulic for control moving stopper and compressed chemical compound. It always causes irregular performances of the column. This paper presents automation control with a servo motor that prevents slurry issues and improves efficiency of the prep column reproducibility and provides easy automation. As an automation method, cortex-m4 as an embedded processor and operating system with LabVIEW, are used to control the HPLC system. To generate the heuristic data for the fuzzy inference control, experiments are conducted to identify correlation between data such as pressure sensor and motor speed. The result will improve performance of the servo prep column of HPLC for automation control based on fuzzy inference control.

Original languageEnglish
Pages (from-to)1135-1140
Number of pages6
JournalJournal of the Korean Society for Precision Engineering
Issue number12
Publication statusPublished - 2019 Dec


  • Automation control system
  • Fuzzy inference control
  • High performance liquid chromatography

ASJC Scopus subject areas

  • Safety, Risk, Reliability and Quality
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering


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