Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.
Bibliographical noteFunding Information:
We would like to thank members of the Overholtzer Laboratory for discussions, and Dr. Oliver Florey for reading the manuscript. This work was financially supported by a grant from the National Cancer Institute ( CA154649 ; M.O.), the Louis V. Gerstner , Jr. Young Investigators Fund (M.O.), and the Benjamin Friedman Research Fund (M.O.). These sponsors had no involvement in the writing of the manuscript or the decision to submit the manuscript for publication.
- Cell death
ASJC Scopus subject areas
- Cancer Research