Autophagy proteins regulate cell engulfment mechanisms that participate in cancer

Sung Eun Kim; Michael Overholtzer

doi:10.1016/j.semcancer.2013.05.004

Autophagy proteins regulate cell engulfment mechanisms that participate in cancer

Sung Eun Kim, Michael Overholtzer

Research output: Contribution to journal › Review article › peer-review

26 Citations (Scopus)

Abstract

Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.

Original language	English
Pages (from-to)	329-336
Number of pages	8
Journal	Seminars in Cancer Biology
Volume	23
Issue number	5
DOIs	https://doi.org/10.1016/j.semcancer.2013.05.004
Publication status	Published - 2013 Oct
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank members of the Overholtzer Laboratory for discussions, and Dr. Oliver Florey for reading the manuscript. This work was financially supported by a grant from the National Cancer Institute ( CA154649 ; M.O.), the Louis V. Gerstner , Jr. Young Investigators Fund (M.O.), and the Benjamin Friedman Research Fund (M.O.). These sponsors had no involvement in the writing of the manuscript or the decision to submit the manuscript for publication.

Keywords

Autophagy
Cell death
Entosis
Immune
Macrophage
Phagocytosis
Tumor

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.semcancer.2013.05.004

Cite this

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title = "Autophagy proteins regulate cell engulfment mechanisms that participate in cancer",

abstract = "Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.",

keywords = "Autophagy, Cell death, Entosis, Immune, Macrophage, Phagocytosis, Tumor",

author = "Kim, {Sung Eun} and Michael Overholtzer",

note = "Funding Information: We would like to thank members of the Overholtzer Laboratory for discussions, and Dr. Oliver Florey for reading the manuscript. This work was financially supported by a grant from the National Cancer Institute ( CA154649 ; M.O.), the Louis V. Gerstner , Jr. Young Investigators Fund (M.O.), and the Benjamin Friedman Research Fund (M.O.). These sponsors had no involvement in the writing of the manuscript or the decision to submit the manuscript for publication.",

year = "2013",

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doi = "10.1016/j.semcancer.2013.05.004",

language = "English",

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AU - Kim, Sung Eun

AU - Overholtzer, Michael

N1 - Funding Information: We would like to thank members of the Overholtzer Laboratory for discussions, and Dr. Oliver Florey for reading the manuscript. This work was financially supported by a grant from the National Cancer Institute ( CA154649 ; M.O.), the Louis V. Gerstner , Jr. Young Investigators Fund (M.O.), and the Benjamin Friedman Research Fund (M.O.). These sponsors had no involvement in the writing of the manuscript or the decision to submit the manuscript for publication.

PY - 2013/10

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N2 - Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.

AB - Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.

KW - Autophagy

KW - Cell death

KW - Entosis

KW - Immune

KW - Macrophage

KW - Phagocytosis

KW - Tumor

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U2 - 10.1016/j.semcancer.2013.05.004

DO - 10.1016/j.semcancer.2013.05.004

M3 - Review article

C2 - 23726896

AN - SCOPUS:84884813475

SN - 1044-579X

VL - 23

SP - 329

EP - 336

JO - Seminars in Cancer Biology

JF - Seminars in Cancer Biology

IS - 5

ER -

Autophagy proteins regulate cell engulfment mechanisms that participate in cancer

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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