Azelaic acid induces cholecystokinin secretion and reduces fat-rich food preference via activation of Olfr544

Moonki Chae, Chunyan Wu, Jaeeun Shin, Sung Joon Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Olfactory receptor 544 (Olfr544) is expressed in extra-nasal tissues and has been shown to reduce adiposity and shift fuel preference to fats. Here, we investigated whether Olfr544 regulates feeding behavior. Azelaic acid increased cholecystokinin (CCK) secretion ex vivo and in vivo by Olfr544 dependently. In a two-food choice study, oral administration of azelaic acid reduced high fat diet (HFD) intake and increased normal diet (ND) intake, which was abolished in Olfr544-knockout mice. In a two-bottle preference test, the oral administration of azelaic acid reduced the intake of linoleic acid solution while increasing the intake of control solution (xanthan gum) and the effect of azelaic acid disappeared in Olfr544-knockout mice. Intraperitoneal injection of proglumide, a CCK-1/2 receptor antagonist, negated the effect of azelaic acid in reducing fat preference. Collectively, our findings suggested that Olfr544 activation by azelaic acid reduced calorie-rich high-fat food intake mediated, at least in part, by CCK secretion.

Original languageEnglish
Article number105577
JournalJournal of Functional Foods
Volume105
DOIs
Publication statusPublished - 2023 Jun

Bibliographical note

Funding Information:
This work was supported by a Ottogi Inc. (Q1917681).

Publisher Copyright:
© 2023

Keywords

  • Azelaic acid
  • Cholecystokinin
  • Ectopic olfactory receptor
  • Fat preference
  • Olfr544

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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