Investigation of the chemical and electrical signals of cells in vivo is critical for studying functional connectivity and brain diseases. Most previous studies have observed either the electrical signals or the chemical signals of cells because recording electrical signals and neurochemicals are done by fundamentally different methods. Herein, we present a bimodal MEMS neural probe that is monolithically integrated with an array of microelectrodes for recording electrical activity, microfluidic channels for sampling extracellular fluid, and a microfluidic interface chip for multiple drug delivery and sample isolation from the localized region at the cellular level. In this work, we successfully demonstrated the functionality of our probe by monitoring and modulating bimodal (electrical and chemical) neural activities through the delivery of chemicals in a co-localized brain region in vivo. We expect our bimodal probe to provide opportunities for a variety of in-depth studies of brain functions as well as for the investigation of neural circuits related to brain diseases.
Bibliographical noteFunding Information:
This work was supported by the Brain Research Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) ( NRF-2017M3C7A1028854 ). Also, this work was supported by the Brain Convergence Research Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) ( NRF-2019M3E5D2A01063814 ), Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) ( NRF-2017M3A9B3061319 ), the Institute for Basic Science ( IBS-R001-D2 ), and Korea Institute of Science and Technology (KIST) intramural grant ( 2E30963 , MI).
- Bimodal neural activity
- Neural probe
- Sampling probe
ASJC Scopus subject areas
- Biomedical Engineering