Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects

Paramesh Jangili; Miae Won; Seo Jin Kim; Jieun Chun; Inseob Shim; Chulhun Kang; Wen Xiu Ren; Jong Seung Kim

doi:10.1021/acsabm.9b00418

Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects

Paramesh Jangili, Miae Won, Seo Jin Kim, Jieun Chun, Inseob Shim, Chulhun Kang, Wen Xiu Ren, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H₂O₂, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.

Original language	English
Pages (from-to)	3532-3539
Number of pages	8
Journal	ACS Applied Bio Materials
Volume	2
Issue number	8
DOIs	https://doi.org/10.1021/acsabm.9b00418
Publication status	Published - 2019 Aug 19

Bibliographical note

Funding Information:
This work was supported by SERB, India (ECR/2015/000035), the programs of the Korean National Research Foundation (NRF) (2018R1A3B1052702, J.S.K.; 2017R1A2A2A05069805, C.K.; 2017R1D1A1B03030062, M.W.), the Korea University Grant (2018–2019), The Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (W.X.R.), and the Basic Science Research Program through the NRF funded by the Ministry of Education (no. 2013R1A1A2062997, W.X.R.).

Publisher Copyright:
© 2019 American Chemical Society.

Keywords

5′-DFUR
COX-2
SN-38
binary drug
synergistic effect

ASJC Scopus subject areas

Biomaterials
General Chemistry
Biomedical Engineering
Biochemistry, medical

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acsabm.9b00418

Cite this

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title = "Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects",

abstract = "We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.",

keywords = "5′-DFUR, COX-2, SN-38, binary drug, synergistic effect",

author = "Paramesh Jangili and Miae Won and Kim, {Seo Jin} and Jieun Chun and Inseob Shim and Chulhun Kang and Ren, {Wen Xiu} and Kim, {Jong Seung}",

note = "Funding Information: This work was supported by SERB, India (ECR/2015/000035), the programs of the Korean National Research Foundation (NRF) (2018R1A3B1052702, J.S.K.; 2017R1A2A2A05069805, C.K.; 2017R1D1A1B03030062, M.W.), the Korea University Grant (2018–2019), The Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (W.X.R.), and the Basic Science Research Program through the NRF funded by the Ministry of Education (no. 2013R1A1A2062997, W.X.R.). Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

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doi = "10.1021/acsabm.9b00418",

language = "English",

volume = "2",

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AU - Jangili, Paramesh

AU - Won, Miae

AU - Kim, Seo Jin

AU - Chun, Jieun

AU - Shim, Inseob

AU - Kang, Chulhun

AU - Ren, Wen Xiu

AU - Kim, Jong Seung

N1 - Funding Information: This work was supported by SERB, India (ECR/2015/000035), the programs of the Korean National Research Foundation (NRF) (2018R1A3B1052702, J.S.K.; 2017R1A2A2A05069805, C.K.; 2017R1D1A1B03030062, M.W.), the Korea University Grant (2018–2019), The Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (W.X.R.), and the Basic Science Research Program through the NRF funded by the Ministry of Education (no. 2013R1A1A2062997, W.X.R.). Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/8/19

Y1 - 2019/8/19

N2 - We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.

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KW - 5′-DFUR

KW - COX-2

KW - SN-38

KW - binary drug

KW - synergistic effect

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Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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