Bioactive components in rice bran oil improve lipid profiles in rats fed a high-cholesterol diet

Tae Youl Ha, Songyi Han, Sung Ran Kim, In Hwan Kim, Hyun Yu Lee, Hye Kyeong Kim

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)


This study examined the effects of bioactive substances in rice bran oil on lipid levels and lipid peroxidation in serum and liver. For 4 weeks, male Sprague-Dawley rats were fed 1 of the following experimental diets: normal diet, high-cholesterol diet, or high-cholesterol diet supplemented with the concentrated bioactive components from rice bran oil (BRBO). The liver cholesterol and triacylglycerol contents were higher in rats fed the high-cholesterol diet than the normal group but significantly decreased by BRBO supplementation. Similarly, hepatic thiobarbituric acid-reactive substances were increased by a high-cholesterol diet and reduced by BRBO supplementation in rats. The high-cholesterol diet increased serum cholesterol and atherogenic index in rats, compared with those fed the normal diet. Serum high-density lipoprotein cholesterol was lowered in the high cholesterol diet group but it was significantly increased in rats of the BRBO group. In addition, BRBO recovered the activities of serum aspartate aminotransferase which was elevated in rats by a high-cholesterol diet. These results suggest that BRBO may play a protective role against the alteration caused by hypercholesterolemic diet in the rat.

Original languageEnglish
Pages (from-to)597-606
Number of pages10
JournalNutrition Research
Issue number6
Publication statusPublished - 2005 Jun

Bibliographical note

Funding Information:
This work was supported by a grant from the Agricultural Research Promotion Center, Ministry of Agriculture, Korea. The authors thank Clifton A. Baile and Cass Nelson-Dooley (Department of Animal and Dairy Science and Food and Nutrition, University of Georgia) for editing the manuscript.


  • HDL cholesterol
  • Lipid peroxidation
  • Rat
  • Rice bran oil
  • Triacylglycerol

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics


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