Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Huayue Li; Byung Cheol Lee; Tae Sung Kim; Kyung Sook Bae; Jongki Hong; Sang Ho Choi; Baoquan Bao; Jee Hyung Jung

doi:10.4062/biomolther.2008.16.4.356

Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Huayue Li, Byung Cheol Lee, Tae Sung Kim, Kyung Sook Bae, Jongki Hong, Sang Ho Choi, Baoquan Bao, Jee Hyung Jung

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.

Original language	English
Pages (from-to)	356-363
Number of pages	8
Journal	Biomolecules and Therapeutics
Volume	16
Issue number	4
DOIs	https://doi.org/10.4062/biomolther.2008.16.4.356
Publication status	Published - 2008 Dec

Keywords

Cyclic dipeptide
D-proline
Psychrobacter sp.
Sponge-associated
Vibrio vulnificus-induced cytotoxicity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4062/biomolther.2008.16.4.356

Cite this

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title = "Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.",

abstract = "A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.",

keywords = "Cyclic dipeptide, D-proline, Psychrobacter sp., Sponge-associated, Vibrio vulnificus-induced cytotoxicity",

author = "Huayue Li and Lee, {Byung Cheol} and Kim, {Tae Sung} and Bae, {Kyung Sook} and Jongki Hong and Choi, {Sang Ho} and Baoquan Bao and Jung, {Jee Hyung}",

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AU - Li, Huayue

AU - Lee, Byung Cheol

AU - Kim, Tae Sung

AU - Bae, Kyung Sook

AU - Hong, Jongki

AU - Choi, Sang Ho

AU - Bao, Baoquan

AU - Jung, Jee Hyung

PY - 2008/12

Y1 - 2008/12

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AB - A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.

KW - Cyclic dipeptide

KW - D-proline

KW - Psychrobacter sp.

KW - Sponge-associated

KW - Vibrio vulnificus-induced cytotoxicity

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DO - 10.4062/biomolther.2008.16.4.356

M3 - Article

AN - SCOPUS:68149178893

SN - 1976-9148

VL - 16

SP - 356

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JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

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ER -

Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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