Bioactive Diterpenoids from the Stems of Euphorbia antiquorum

Yue Liang, Lijun An, Zhaoyu Shi, Xuke Zhang, Chunfeng Xie, Muhetaer Tuerhong, Zhaohui Song, Yasushi Ohizumi, Dongho Lee, Ling Shuai, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.

Original languageEnglish
Pages (from-to)1634-1644
Number of pages11
JournalJournal of Natural Products
Issue number6
Publication statusPublished - 2019 Jun 28

Bibliographical note

Funding Information:
This research was supported financially by the National Natural Science Foundation of China (Nos. U1703107 and U1801288), the National Key Research and Development Program of China (No. 2018YFA0507204), the Fundamental Research Funds for the Central Universities (Nankai University, No. 63191142), Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02).

Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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