Bioactive diterpenoids from the stems of euphorbia royleana

Peixia Wang; Chunfeng Xie; Lijun An; Xueyuan Yang; Yaru Xi; Shuo Yuan; Chenyue Zhang; Muhetaer Tuerhong; Da Qing Jin; Dongho Lee; Jie Zhang; Yasushi Ohizumi; Jing Xu; Yuanqiang Guo

doi:10.1021/acs.jnatprod.8b00493

Bioactive diterpenoids from the stems of euphorbia royleana

Peixia Wang, Chunfeng Xie, Lijun An, Xueyuan Yang, Yaru Xi, Shuo Yuan, Chenyue Zhang, Muhetaer Tuerhong, Da Qing Jin, Dongho Lee, Jie Zhang, Yasushi Ohizumi, Jing Xu, Yuanqiang Guo

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC ₅₀ values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.

Original language	English
Pages (from-to)	183-193
Number of pages	11
Journal	Journal of Natural Products
Volume	82
Issue number	2
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00493
Publication status	Published - 2019 Feb 22

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), the National Key Research and Development Program of China (No. 2018YFA0507204), the Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the Fundamental Research Funds for the Central Universities.

Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.8b00493

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title = "Bioactive diterpenoids from the stems of euphorbia royleana",

abstract = " Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12. ",

author = "Peixia Wang and Chunfeng Xie and Lijun An and Xueyuan Yang and Yaru Xi and Shuo Yuan and Chenyue Zhang and Muhetaer Tuerhong and Jin, {Da Qing} and Dongho Lee and Jie Zhang and Yasushi Ohizumi and Jing Xu and Yuanqiang Guo",

note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), the National Key Research and Development Program of China (No. 2018YFA0507204), the Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the Fundamental Research Funds for the Central Universities. Publisher Copyright: {\textcopyright} 2019 American Chemical Society and American Society of Pharmacognosy.",

year = "2019",

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doi = "10.1021/acs.jnatprod.8b00493",

language = "English",

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AU - Wang, Peixia

AU - Xie, Chunfeng

AU - An, Lijun

AU - Yang, Xueyuan

AU - Xi, Yaru

AU - Yuan, Shuo

AU - Zhang, Chenyue

AU - Tuerhong, Muhetaer

AU - Jin, Da Qing

AU - Lee, Dongho

AU - Zhang, Jie

AU - Ohizumi, Yasushi

AU - Xu, Jing

AU - Guo, Yuanqiang

N1 - Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), the National Key Research and Development Program of China (No. 2018YFA0507204), the Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the Fundamental Research Funds for the Central Universities. Publisher Copyright: © 2019 American Chemical Society and American Society of Pharmacognosy.

PY - 2019/2/22

Y1 - 2019/2/22

N2 - Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.

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Bioactive diterpenoids from the stems of euphorbia royleana

Abstract

Bibliographical note

ASJC Scopus subject areas

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