Bioactive diterpenoids from the stems of euphorbia royleana

Peixia Wang, Chunfeng Xie, Lijun An, Xueyuan Yang, Yaru Xi, Shuo Yuan, Chenyue Zhang, Muhetaer Tuerhong, Da Qing Jin, Dongho Lee, Jie Zhang, Yasushi Ohizumi, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.

Original languageEnglish
Pages (from-to)183-193
Number of pages11
JournalJournal of Natural Products
Volume82
Issue number2
DOIs
Publication statusPublished - 2019 Feb 22

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), the National Key Research and Development Program of China (No. 2018YFA0507204), the Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the Fundamental Research Funds for the Central Universities.

Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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