Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Eun Kyoung Seo; Dongho Lee; Geun Shin Young; Hee Byung Chai; Hernán A. Navarro; Leonardus B.S. Kardono; Ismail Rahman; Geoffrey A. Cordell; Norman R. Farnsworth; John M. Pezzuto; A. Douglas Kinghorn; Mansukh C. Wani; Monroe E. Wall

doi:10.1007/bf02976656

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Eun Kyoung Seo
, Dongho Lee
, Geun Shin Young
, Hee Byung Chai
, Hernán A. Navarro
, Leonardus B.S. Kardono
, Ismail Rahman
, Geoffrey A. Cordell
, Norman R. Farnsworth
, John M. Pezzuto
, A. Douglas Kinghorn
, Mansukh C. Wani^*
, Monroe E. Wall

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

Original language	English
Pages (from-to)	124-127
Number of pages	4
Journal	Archives of pharmacal research
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/bf02976656
Publication status	Published - 2003 Feb 28
Externally published	Yes

Keywords

Artocarpus kemando
Cytotoxicity
DNA strand-scission activity
Flavonoids
LC-MS dereplication
Moraceae

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/bf02976656

Cite this

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title = "Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando",

abstract = "Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.",

keywords = "Artocarpus kemando, Cytotoxicity, DNA strand-scission activity, Flavonoids, LC-MS dereplication, Moraceae",

author = "Seo, \{Eun Kyoung\} and Dongho Lee and Young, \{Geun Shin\} and Chai, \{Hee Byung\} and Navarro, \{Hern{\'a}n A.\} and Kardono, \{Leonardus B.S.\} and Ismail Rahman and Cordell, \{Geoffrey A.\} and Farnsworth, \{Norman R.\} and Pezzuto, \{John M.\} and Kinghorn, \{A. Douglas\} and Wani, \{Mansukh C.\} and Wall, \{Monroe E.\}",

year = "2003",

month = feb,

day = "28",

doi = "10.1007/bf02976656",

language = "English",

volume = "26",

pages = "124--127",

journal = "Archives of pharmacal research",

issn = "0253-6269",

publisher = "Pharmaceutical Society of Korea",

number = "2",

}

TY - JOUR

T1 - Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

AU - Seo, Eun Kyoung

AU - Lee, Dongho

AU - Young, Geun Shin

AU - Chai, Hee Byung

AU - Navarro, Hernán A.

AU - Kardono, Leonardus B.S.

AU - Rahman, Ismail

AU - Cordell, Geoffrey A.

AU - Farnsworth, Norman R.

AU - Pezzuto, John M.

AU - Kinghorn, A. Douglas

AU - Wani, Mansukh C.

AU - Wall, Monroe E.

PY - 2003/2/28

Y1 - 2003/2/28

N2 - Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

AB - Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

KW - Artocarpus kemando

KW - Cytotoxicity

KW - DNA strand-scission activity

KW - Flavonoids

KW - LC-MS dereplication

KW - Moraceae

UR - https://www.scopus.com/pages/publications/0043288772

U2 - 10.1007/bf02976656

DO - 10.1007/bf02976656

M3 - Article

C2 - 12643587

AN - SCOPUS:0043288772

SN - 0253-6269

VL - 26

SP - 124

EP - 127

JO - Archives of pharmacal research

JF - Archives of pharmacal research

IS - 2

ER -

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Abstract

Keywords

ASJC Scopus subject areas

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