Abstract
A phytochemical investigation to obtain new NO inhibitors resulted in the identification of six new (1-6) and four known (7-10) terpenoids from Salvia plebeia. Compounds 1 and 2 are new diterpenoids, 3-5 are new meroditerpenoids, 6-9 are sesquiterpenoids, and 10 is a known meroditerpenoid. The structures of these isolates were determined by routine NMR experiments and X-ray diffraction, as well as the electronic circular dichroism spectra. Compounds 1-4 are diterpenoids carrying an oxygen bridge, and 6 is a rare copane-type sesquiterpenoid with a bridged tricyclic framework. The isolates inhibited NO generation induced by lipopolysaccharide in BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed interactions of bioactive compounds with the iNOS protein.
| Original language | English |
|---|---|
| Pages (from-to) | 2924-2932 |
| Number of pages | 9 |
| Journal | Journal of Natural Products |
| Volume | 79 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2016 Nov 23 |
Bibliographical note
Funding Information:This research was financially supported by the National Natural Science Foundation of China (No. 21372125), the Ministry of Science & Technology 973 Project (No. 2014CB560709), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the State Key Laboratory of Medicinal Chemical Biology (No. 201602007).
Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry