Bioactive triterpenoids from callistemon lanceolatus

Wonsik Jeong; Seong Su Hong; Nahyun Kim; Young Taek Yang; Yu Su Shin; Chul Lee; Bang Yeon Hwang; Dongho Lee

doi:10.1007/s12272-009-1605-3

Bioactive triterpenoids from callistemon lanceolatus

Wonsik Jeong, Seong Su Hong, Nahyun Kim, Young Taek Yang, Yu Su Shin, Chul Lee, Bang Yeon Hwang, Dongho Lee

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.

Original language	English
Pages (from-to)	845-849
Number of pages	5
Journal	Archives of pharmacal research
Volume	32
Issue number	6
DOIs	https://doi.org/10.1007/s12272-009-1605-3
Publication status	Published - 2009 Jun

Bibliographical note

Funding Information:
This work was supported by a Korea University (KU) Grant to D. Lee. We thank Cooperative Center for Analytical Instruments at KU for providing some of the equipment used in this study.

Keywords

Betulinic acid 3-O-caffeate
Callistemon lanceolatus
Myrtaceae
NO production inhibitor
Triterpenoids

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Organic Chemistry

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10.1007/s12272-009-1605-3

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title = "Bioactive triterpenoids from callistemon lanceolatus",

abstract = "A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.",

keywords = "Betulinic acid 3-O-caffeate, Callistemon lanceolatus, Myrtaceae, NO production inhibitor, Triterpenoids",

author = "Wonsik Jeong and Hong, {Seong Su} and Nahyun Kim and Yang, {Young Taek} and Shin, {Yu Su} and Chul Lee and Hwang, {Bang Yeon} and Dongho Lee",

note = "Funding Information: This work was supported by a Korea University (KU) Grant to D. Lee. We thank Cooperative Center for Analytical Instruments at KU for providing some of the equipment used in this study.",

year = "2009",

month = jun,

doi = "10.1007/s12272-009-1605-3",

language = "English",

volume = "32",

pages = "845--849",

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AU - Jeong, Wonsik

AU - Hong, Seong Su

AU - Kim, Nahyun

AU - Yang, Young Taek

AU - Shin, Yu Su

AU - Lee, Chul

AU - Hwang, Bang Yeon

AU - Lee, Dongho

N1 - Funding Information: This work was supported by a Korea University (KU) Grant to D. Lee. We thank Cooperative Center for Analytical Instruments at KU for providing some of the equipment used in this study.

PY - 2009/6

Y1 - 2009/6

N2 - A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.

AB - A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.

KW - Betulinic acid 3-O-caffeate

KW - Callistemon lanceolatus

KW - Myrtaceae

KW - NO production inhibitor

KW - Triterpenoids

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DO - 10.1007/s12272-009-1605-3

M3 - Article

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SN - 0253-6269

VL - 32

SP - 845

EP - 849

JO - Archives of pharmacal research

JF - Archives of pharmacal research

IS - 6

ER -

Bioactive triterpenoids from callistemon lanceolatus

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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