Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

Peng Wu, Ziteng Song, Xuelian Wang, Ying Li, Yuhao Li, Jianlin Cui, Muhetaer Tuerhong, Da Qing Jin, Munira Abudukeremu, Dongho Lee, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1–4) and six known (6–10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1–4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.

Original languageEnglish
Article number104004
JournalBioorganic Chemistry
Volume101
DOIs
Publication statusPublished - 2020 Aug

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 and U1801288 ), the Natural Science Foundation of Tianjin , China (No. 19JCYBJC28100 ), the Hundred Young Academic Leaders Program of Nankai University , the State Key Laboratory of Drug Research (No. SIMM2004KF-13 ), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019 ).

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

  • Anti-inflammatory properties
  • Euphane triterpenoids
  • Lantana camara
  • Molecular docking
  • Zebrafish model

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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