Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

Peng Wu; Ziteng Song; Xuelian Wang; Ying Li; Yuhao Li; Jianlin Cui; Muhetaer Tuerhong; Da Qing Jin; Munira Abudukeremu; Dongho Lee; Jing Xu; Yuanqiang Guo

doi:10.1016/j.bioorg.2020.104004

Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

Peng Wu, Ziteng Song, Xuelian Wang, Ying Li, Yuhao Li, Jianlin Cui, Muhetaer Tuerhong, Da Qing Jin, Munira Abudukeremu, Dongho Lee, Jing Xu, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1–4) and six known (6–10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1–4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.

Original language	English
Article number	104004
Journal	Bioorganic Chemistry
Volume	101
DOIs	https://doi.org/10.1016/j.bioorg.2020.104004
Publication status	Published - 2020 Aug

Keywords

Anti-inflammatory properties
Euphane triterpenoids
Lantana camara
Molecular docking
Zebrafish model

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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10.1016/j.bioorg.2020.104004

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title = "Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo",

abstract = "Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1–4) and six known (6–10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1–4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.",

keywords = "Anti-inflammatory properties, Euphane triterpenoids, Lantana camara, Molecular docking, Zebrafish model",

author = "Peng Wu and Ziteng Song and Xuelian Wang and Ying Li and Yuhao Li and Jianlin Cui and Muhetaer Tuerhong and Jin, {Da Qing} and Munira Abudukeremu and Dongho Lee and Jing Xu and Yuanqiang Guo",

note = "Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 and U1801288 ), the Natural Science Foundation of Tianjin , China (No. 19JCYBJC28100 ), the Hundred Young Academic Leaders Program of Nankai University , the State Key Laboratory of Drug Research (No. SIMM2004KF-13 ), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019 ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = aug,

doi = "10.1016/j.bioorg.2020.104004",

language = "English",

volume = "101",

journal = "Bioorganic Chemistry",

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publisher = "Academic Press Inc.",

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T1 - Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

AU - Wu, Peng

AU - Song, Ziteng

AU - Wang, Xuelian

AU - Li, Ying

AU - Li, Yuhao

AU - Cui, Jianlin

AU - Tuerhong, Muhetaer

AU - Jin, Da Qing

AU - Abudukeremu, Munira

AU - Lee, Dongho

AU - Xu, Jing

AU - Guo, Yuanqiang

N1 - Funding Information: This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 and U1801288 ), the Natural Science Foundation of Tianjin , China (No. 19JCYBJC28100 ), the Hundred Young Academic Leaders Program of Nankai University , the State Key Laboratory of Drug Research (No. SIMM2004KF-13 ), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019 ). Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/8

Y1 - 2020/8

N2 - Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1–4) and six known (6–10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1–4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.

AB - Bioactive natural products play an important role in the research and development of new drugs. In our search for bioactive natural substances as potential lead compounds for inflammation, four new (1–4) and six known (6–10) triterpenoids were acquired from Lantana camara. Using NMR and MS techniques and electronic circular dichroism (ECD) calculations, these isolates were characterized and the new compounds (1–4) were found to be euphane-type triterpenoids. The in vitro anti-inflammatory effects of all the isolates were evaluated and the more bioactive compounds were selected for the investigation of preliminary mechanism using molecular docking and Western blotting experiments, as well as the in vivo anti-inflammatory evaluation using a zebrafish model.

KW - Anti-inflammatory properties

KW - Euphane triterpenoids

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KW - Zebrafish model

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SN - 0045-2068

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JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

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Bioactive triterpenoids from Lantana camara showing anti-inflammatory activities in vitro and in vivo

Abstract

Keywords

ASJC Scopus subject areas

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