Biocompatible cracked reduced graphene oxide strain sensors: enhancing implantable strain sensing performance and durability

Hyun Joo Lee, Bokyeong Ryu, Dong Keon Lee, Hyung Ju Park, Chul Huh, Dong Ick Son, Dong Han Ha, C. Yoon Kim, Yongseok Jun, Yong Ju Yun

Research output: Contribution to journalArticlepeer-review

Abstract

Implantable strain sensors that reliably detect various biomechanical signals in vivo are essential electronic devices for advanced biomedical and bioengineering technologies. However, it is a challenge to prepare soft implantable strain sensors with high linear sensitivity, good mechanical/chemical stability, and proper biological compatibility. Here, we report the preparation, mechanics, and applications of soft and implantable cracked reduced graphene oxide-based electro-mechanical strain sensors for monitoring internal tissue or organ dynamics that also address the aforementioned limitations. These skin-like strain sensors are composed of a high-quality microwaved reduced graphene oxide multilayer and a microcracked polymer substrate. By adopting both prestrain and hybrid reduction strategies, we successfully developed novel implantable graphene strain sensors that exhibit a set of unique properties, including high strain linear sensitivity (∼876.7 GF over a range of 0% to 30% strain), excellent mechanical durability (10 000 strain cycles at a strain of 20%) and chemical stability in biological fluids (a saline solution for 7 days), and excellent in vitro and in vivo biocompatibility. We also demonstrated the use of our implantable sensors for reliably measuring the strain associated with in vivo dynamic cardiac activity and for assessing preclinical cardiovascular drugs.

Original languageEnglish
Pages (from-to)8405-8412
Number of pages8
JournalJournal of Materials Chemistry C
Volume11
Issue number25
DOIs
Publication statusPublished - 2023 May 30

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education (NRF-2022R1I1A1A01069248) and Institute of Information & communications Technology Planning & Evaluation (IITP) grant funded by the Korea government (MSIT-2022-0-00025) and the Korea Institute of Energy Technology Evaluation and Planning (KETEP) granted financial resource from the Ministry of Trade, Industry & Energy, Republic of Korea (No. 20213091010020) and from a Korea University Grant, and by the KU-KIST Graduate School Project.

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Biocompatible cracked reduced graphene oxide strain sensors: enhancing implantable strain sensing performance and durability'. Together they form a unique fingerprint.

Cite this