Bioconversion of 12-, 14-, and 16-membered ring aglycones to glycosylated macrolides in an engineered strain of Streptomyces venezuelae

Keyphrases

• 16-membered Ring 100%
• Aglycone 100%
• Auxiliary Proteins 50%
• Bioconversion 100%
• Biosynthetic Enzymes 25%
• Biosynthetic Gene Clusters 25%
• Biosynthetic Pathway 25%
• Combinatorial Biosynthesis 25%
• Deoxy Sugar 25%
• Desosamine 25%
• Diphosphate 100%
• Engineered Strain 100%
• Glycosyltransferase 100%
• In Vivo System 25%
• Macrolactone 25%
• Macrolide Antibiotics 25%
• Macrolides 100%
• Mutant Strains 75%
• Pikromycin 25%
• Polyketide Synthase 25%
• Protein Pairs 50%
• Streptomyces Fradiae 25%
• Streptomyces Venezuelae 100%
• Substrate Flexibility 25%
• Substrate Specificity 25%
• Thymidine 100%

Pharmacology, Toxicology and Pharmaceutical Science

• Aglycone 100%
• Antibiotics 20%
• Combinatorial Biosynthesis 20%
• Deoxysugar 20%
• Glycosyltransferase 80%
• Macrolide 100%
• Pikromycin 20%
• Polyketide Synthase 20%
• Streptomyces fradiae 20%
• Streptomyces Venezuelae 100%
• Substrate Specificity 20%
• Thymidine Diphosphate 80%

Chemistry

• 10-Deoxymethynolide 40%
• Bioconversion 100%
• Biosynthesis 20%
• Deoxy Sugar 20%
• Desosamine 20%
• Macrolide Antibiotic Agent 100%
• Narbonolide 40%
• Pikromycin 20%
• Polyketide 20%
• Quinovose 60%
• Substrate Specificity 20%
• Thymidine 80%
• Tylactone 40%