Biological aging modulates cell migration via lamin A/C-dependent nuclear motion

Jung Won Park, Seong Beom Han, Jungwon Hah, Geonhui Lee, Jeong Ki Kim, Soo Hyun Kim, Dong Hwee Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Aging is a progressive functional decline in organs and tissues over time and typically represents the accumulation of psychological and social changes in a human being. Diverse diseases, such as cardiovascular, musculoskeletal, and neurodegenerative disorders, are now understood to be caused by aging. While biological assessment of aging mainly focuses on the gradual changes that occur either on the molecular scale, for example, alteration of gene expression and epigenetic modification, or on larger scales, for example, changes in muscle strength and cardiac function, the mechanics that regulates the behavior of individual cells and interactions between the internal elements of cells, are largely missing. In this study, we show that the dynamic features of migrating cells across different human ages could help to establish the underlying mechanism of biological age-dependent cellular functional decline. To determine the relationship between cellular dynamics and human age, we identify the characteristic relationship between cell migration and nuclear motion which is tightly regulated by nucleus-bound cytoskeletal organization. This analysis demonstrates that actomyosin contractility-dependent nuclear motion plays a key role in cell migration. We anticipate this study to provide noble biophysical insights on biological aging in order to precisely diagnose age-related chronic diseases.

Original languageEnglish
Article number801
Issue number9
Publication statusPublished - 2020 Sept

Bibliographical note

Funding Information:
Acknowledgments: Authors thank members of the Applied Mechanobiology Group at the Korea University for thoughtful discussion. This work was supported by KU-KIST Graduate School of Converging Science and Technology Program, Korea University Future R esearch Grants, Korea University Grant, and National Research Foundation of Korea.

Funding Information:
Funding: This research was funded by National Research Foundation of Korea, grant number 2019R1A2C2004437.

Publisher Copyright:
© 2020 by the authors.


  • Aging
  • Cell motility
  • Lamin A/C
  • Nuclear dynamics

ASJC Scopus subject areas

  • Control and Systems Engineering
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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