Biological lipid membranes for on-demand, wireless drug delivery from thin, bioresorbable electronic implants

Chi Hwan Lee, Hojun Kim, Daniel V. Harburg, Gayoung Park, Yinji Ma, Taisong Pan, Jae Soon Kim, Na Yeon Lee, Bong Hoon Kim, Kyung In Jang, Seung Kyun Kang, Yonggang Huang, Jeongmin Kim, Kyung Mi Lee, Cecilia Leal, John A. Rogers

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)

Abstract

On-demand, localized release of drugs in precisely controlled, patient-specific time sequences represents an ideal scenario for pharmacological treatment of various forms of hormone imbalances, malignant cancers, osteoporosis, diabetic conditions and others. We present a wirelessly operated, implantable drug delivery system that offers such capabilities in a form that undergoes complete bioresorption after an engineered functional period, thereby obviating the need for surgical extraction. The device architecture combines thermally actuated lipid membranes embedded with multiple types of drugs, configured in spatial arrays and co-located with individually addressable, wireless elements for Joule heating. The result provides the ability for externally triggered, precision dosage of drugs with high levels of control and negligible unwanted leakage, all without the need for surgical removal. In vitro and in vivo investigations reveal all of the underlying operational and materials aspects, as well as the basic efficacy and biocompatibility of these systems.

Original languageEnglish
Article numbere227
JournalNPG Asia Materials
Volume7
Issue number11
DOIs
Publication statusPublished - 2015 Nov 13

Bibliographical note

Funding Information:
The authors gratefully acknowledge support from NSF-INSPIRE Grant (DMR-1242240). CL would like to thank the Campus Research Board, Frederick Seitz Materials Research Laboratory, and Materials Science and Engineering at University of Illinois at Urbana-Champaign. K-ML would like to thank the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP (2007-00107 and 2013M3A9D3045719). YH acknowledges the support from NSF (CMMI-1300846 and CMMI-1400169) and the NIH (grant no. R01EB019337). CHL would like to thank the supports from the Weldon School of Biomedical Engineering and the School of Mechanical Engineering at Purdue University.

ASJC Scopus subject areas

  • Modelling and Simulation
  • General Materials Science
  • Condensed Matter Physics

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