Biological methylation of myelin basic protein: Enzymology and biological significance

Sangduk Kim, In Kyoung Lim, Gil Hong Park, Woon Ki Paik

    Research output: Contribution to journalReview articlepeer-review

    72 Citations (Scopus)


    Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximatelg 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP has an unusual amino acid at Res-107 as a mixture of N(G)-monomethylarginine and N(G), N(G)-dimethylarginine. The formation of these methylarginine derivatives is catalysed by one of the subtypes of protein methylase I, which specifically methylates Res-107 of this protein. Evidence is presented to demonstrate an involvement of this biological methylation in the integrity and maintenance of myelin.

    Original languageEnglish
    Pages (from-to)743-751
    Number of pages9
    JournalInternational Journal of Biochemistry and Cell Biology
    Issue number5
    Publication statusPublished - 1997 May

    Bibliographical note

    Funding Information:
    Acknowledgement.s-This work was partially supported by “Brain Pool” grants from Korea Science and Engineering Foundation to S. Kim and W. K. Paik, and by grant No. 95-102 to I. K. and No. 055 to G-H. Park from the Korea Ministry cf Education.


    • MBP methylation
    • Multiple sclerosis
    • Myelin basic protein
    • Protein-arginine methylation

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology


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