Bioorthogonal copper-free click chemistry inVivo for tumor-targeted delivery of nanoparticles

Heebeom Koo, Sangmin Lee, Jin Hee Na, Sun Hwa Kim, Sei Kwang Hahn, Kuiwon Choi, Ick Chan Kwon, Seo Young Jeong, Kwangmeyung Kim

Research output: Contribution to journalArticlepeer-review

209 Citations (Scopus)


Right on target: An invivo tumor-targeting strategy using nanoparticles has been developed. An unnatural sialic acid (green, see scheme) with azide groups is artificially generated on the target site by metabolic glycoengineering. These groups then effectively enhance the accumulation of nanoparticles in the target tumor site by an invivo bioorthogonal copper-free click reaction.

Original languageEnglish
Pages (from-to)11836-11840
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number47
Publication statusPublished - 2012 Nov 19
Externally publishedYes


  • click chemistry
  • drug delivery
  • metabolic glycoengineering
  • nanoparticle
  • tumor targeting

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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