A strategy of materials synthesis, characteristic evaluations, and manufacturing process for a mechanically elastic, biologically safe silicon-based dopamine detector that is designed to be completely transient, i.e., dissolved in water and/or biofluids, potentially in the brain after a desired period of operation, is introduced. Use of inexpensive, bioresorbable iron (Fe)-based nanoparticles (NPs) is one of the attractive choices for efficient catalytic oxidation of dopamine as an alternative for noble, nontransient platinum (Pt) nanoparticles, based on extensive studies of synthesized materials and catalytic reactions. Arrays of transient dopamine sensors validate electrochemical functionality to determine physiological levels of dopamine and to selectively sense dopamine in a variety of neurotransmitters, illuminating feasibilities for a higher level of soft, transient electronic implants integrated with other components of overall system.
Bibliographical noteFunding Information:
H.-S.K. and S.M.Y. contributed equally to this work. This work was supported by KU-KIST Graduate School of Converging Science and Technology Program, KU Future Research Grant, the KIST project (2E27930), and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of science, ICT & Future Planning (grant NRF-2017R1E1A1A01075027).
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- dopamine sensors
- iron catalyst
ASJC Scopus subject areas
- Biomedical Engineering
- Pharmaceutical Science