Biosensors: Aptamer Sensors

Bang Hyun Lee, Sang Hoon Kim, Man Bock Gu

Research output: Chapter in Book/Report/Conference proceedingChapter


Aptamers are an up-and-coming bioreceptor in application spanning from environmental monitoring to clinical diagnosis and therapeutic usage due to their relatively small size, chemical stability, easy modifications, and environmental compatibility over conventional bioreceptors. Together with the high demand for efficient biosensors, recent advances in nanobiotechnology have drawn many researchers’ keen attention to the development of innovative aptasensors that are performing rapidly and thoroughly with high sensitivity and selectivity to their target analytes. In this review, overview of aptamer screening methodologies is briefly discussed, and then different types of aptamer-based biosensor platforms with their state-of-the-art applications are described. Several practical challenges on aptasensor development are also discussed to overcome their limited commercialization. Furthermore, perspectives on the promising future of aptasensors in application stretching across point-of-care technologies are addressed.

Original languageEnglish
Title of host publicationEncyclopedia of Sensors and Biosensors
Subtitle of host publicationVolume 1-4, First Edition
Number of pages14
ISBN (Electronic)9780128225486
ISBN (Print)9780128225493
Publication statusPublished - 2022 Jan 1

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd. All rights reserved


  • Aptamer
  • Aptasensor
  • BLI-based aptasensor
  • Biosensor
  • Colorimetric aptasensor
  • Electrochemical aptasensor
  • Fluorescence aptasensor
  • LFA-based aptasensor
  • Optical sensor
  • QCM-based aptasensor
  • SERS-based aptasensor
  • SPR-based aptasensor
  • Smartphone-based aptasensor

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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