Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Dongho Lee; Kyeong Lee; Xing Fu Cai; Nguyen Tien Dat; Shanthaveerappa K. Boovanahalli; Mijeoung Lee; Jin Chul Shin; Woncheol Kim; Jae Kap Jeong; Jong Suk Lee; Choong Hwan Lee; Jeong Hyung Lee; Young Soo Hong; Jung Joon Lee

doi:10.1002/cbic.200500441

Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Dongho Lee, Kyeong Lee, Xing Fu Cai, Nguyen Tien Dat, Shanthaveerappa K. Boovanahalli, Mijeoung Lee, Jin Chul Shin, Woncheol Kim, Jae Kap Jeong, Jong Suk Lee, Choong Hwan Lee, Jeong Hyung Lee, Young Soo Hong, Jung Joon Lee

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

Original language	English
Pages (from-to)	246-248
Number of pages	3
Journal	ChemBioChem
Volume	7
Issue number	2
DOIs	https://doi.org/10.1002/cbic.200500441
Publication status	Published - 2006 Feb
Externally published	Yes

Keywords

Antitumor agents
Autooxidation
Biosynthesis
Polyketides

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.200500441

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title = "Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety",

abstract = "A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.",

keywords = "Antitumor agents, Autooxidation, Biosynthesis, Polyketides",

author = "Dongho Lee and Kyeong Lee and Cai, {Xing Fu} and Dat, {Nguyen Tien} and Boovanahalli, {Shanthaveerappa K.} and Mijeoung Lee and Shin, {Jin Chul} and Woncheol Kim and Jeong, {Jae Kap} and Lee, {Jong Suk} and Lee, {Choong Hwan} and Lee, {Jeong Hyung} and Hong, {Young Soo} and Lee, {Jung Joon}",

year = "2006",

month = feb,

doi = "10.1002/cbic.200500441",

language = "English",

volume = "7",

pages = "246--248",

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T2 - New insight into the formation of the benzoquinone moiety

AU - Lee, Dongho

AU - Lee, Kyeong

AU - Cai, Xing Fu

AU - Dat, Nguyen Tien

AU - Boovanahalli, Shanthaveerappa K.

AU - Lee, Mijeoung

AU - Shin, Jin Chul

AU - Kim, Woncheol

AU - Jeong, Jae Kap

AU - Lee, Jong Suk

AU - Lee, Choong Hwan

AU - Lee, Jeong Hyung

AU - Hong, Young Soo

AU - Lee, Jung Joon

PY - 2006/2

Y1 - 2006/2

N2 - A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

AB - A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

KW - Antitumor agents

KW - Autooxidation

KW - Biosynthesis

KW - Polyketides

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Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Abstract

Keywords

ASJC Scopus subject areas

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