Biotin-guided anticancer drug delivery with acidity-triggered drug release

Soyeon Park; Eunjin Kim; Won Young Kim; Chulhun Kang; Jong Seung Kim

doi:10.1039/c5cc03003j

Biotin-guided anticancer drug delivery with acidity-triggered drug release

Soyeon Park, Eunjin Kim, Won Young Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

Original language	English
Pages (from-to)	9343-9345
Number of pages	3
Journal	Chemical Communications
Volume	51
Issue number	45
DOIs	https://doi.org/10.1039/c5cc03003j
Publication status	Published - 2015 Jun 7

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Biotin-guided anticancer drug delivery with acidity-triggered drug release",

abstract = "A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.",

author = "Soyeon Park and Eunjin Kim and Kim, {Won Young} and Chulhun Kang and Kim, {Jong Seung}",

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AU - Park, Soyeon

AU - Kim, Eunjin

AU - Kim, Won Young

AU - Kang, Chulhun

AU - Kim, Jong Seung

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015/6/7

Y1 - 2015/6/7

N2 - A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

AB - A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

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DO - 10.1039/c5cc03003j

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AN - SCOPUS:84930211772

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SP - 9343

EP - 9345

JO - Chemical Communications

JF - Chemical Communications

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Biotin-guided anticancer drug delivery with acidity-triggered drug release

Abstract

ASJC Scopus subject areas

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