Birefringent particles as an effective factor in usual interstitial pneumonia

Min Jung Kim, Seung Yeon Ha, Sung Hwan Jeong, Bongkyung Shin

    Research output: Contribution to journalArticlepeer-review


    Background: It has long been recognized that birefringent paticles (BP) are associated with pulmonary disease. And there is increasing evidence that BP cause fibrotic reaction within the lung depending on both particle size and composition. Methods: We collected 41 cases of usual interstitial pneumonia (UIP) and 101 cases of normal lung tissue from control group including squamous cell carcinoma, adenocarcinoma and bullae. BPs in the 0:1 to 10 μm size range under polarizing microscope was measured and counted by image analyzer. Results: BP counts are mean 244.05/10 HPF in UIP and 71.4/10 HPF in control group. BPs in UIP is three times more than control (p=0.000). It increased significantly by the age of patients (p=0.000). Conclusions: BPs in lung might be important cause of inflammation and fibrosis in UIP.

    Original languageEnglish
    Pages (from-to)198-201
    Number of pages4
    JournalKorean Journal of Pathology
    Issue number4
    Publication statusPublished - 2008


    • Dust
    • Interstitial
    • Pneumonias
    • Polarization microscopy

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine


    Dive into the research topics of 'Birefringent particles as an effective factor in usual interstitial pneumonia'. Together they form a unique fingerprint.

    Cite this