Birefringent particles as an effective factor in usual interstitial pneumonia

Min Jung Kim, Seung Yeon Ha, Sung Hwan Jeong, Bongkyung Shin

Research output: Contribution to journalArticlepeer-review


Background: It has long been recognized that birefringent paticles (BP) are associated with pulmonary disease. And there is increasing evidence that BP cause fibrotic reaction within the lung depending on both particle size and composition. Methods: We collected 41 cases of usual interstitial pneumonia (UIP) and 101 cases of normal lung tissue from control group including squamous cell carcinoma, adenocarcinoma and bullae. BPs in the 0:1 to 10 μm size range under polarizing microscope was measured and counted by image analyzer. Results: BP counts are mean 244.05/10 HPF in UIP and 71.4/10 HPF in control group. BPs in UIP is three times more than control (p=0.000). It increased significantly by the age of patients (p=0.000). Conclusions: BPs in lung might be important cause of inflammation and fibrosis in UIP.

Original languageEnglish
Pages (from-to)198-201
Number of pages4
JournalKorean Journal of Pathology
Issue number4
Publication statusPublished - 2008
Externally publishedYes


  • Dust
  • Interstitial
  • Pneumonias
  • Polarization microscopy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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