TY - JOUR
T1 - Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother–neonate pairs
AU - Lee, Jangwoo
AU - Choi, Kyungho
AU - Park, Jeongim
AU - Moon, Hyo Bang
AU - Choi, Gyuyeon
AU - Lee, Jeong Jae
AU - Suh, Eunsook
AU - Kim, Hai Joong
AU - Eun, So Hee
AU - Kim, Gun Ha
AU - Cho, Geum Joon
AU - Kim, Sung Koo
AU - Kim, Sungjoo
AU - Kim, Su Young
AU - Kim, Seunghyo
AU - Eom, Soyong
AU - Choi, Sooran
AU - Kim, Young Don
AU - Kim, Sungkyoon
N1 - Funding Information:
This study used the biological samples collected through a study funded the Ministry of the Food and Drug Safety ( 12162MFDS731 ) in 2012. This study was supported by Ministry of the Food and Drug Safety ( 14162MFDS703 ) in 2014 and Korea Environmental Industry and Technology Institute ( 2015001940002 ) in 2015.
Publisher Copyright:
© 2017
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios in mother–neonate paired samples. Maternal serum, urine, placenta, breast milk, cord serum, and neonatal urine samples were collected from 318 mother–neonate pairs at six university hospitals in Korea. BPA levels were detected using liquid chromatography tandem mass spectrometry. The ratios of the BPA levels in the other sample types to the levels in maternal serum were calculated. BPA was detected in 79.5–100% of the maternal and fetal samples. The median BPA concentration in the samples decreased in the order of neonatal urine (4.75 ng/mL), maternal urine (2.86 ng/mL), cord serum (1.71 ng/mL), maternal serum (1.56 ng/mL), breast milk (0.74 ng/mL), and the placenta (0.53 ng/g). We estimated the ratios of BPA levels in the other sample types to those in maternal serum. The median (95th percentile) cord serum-to-maternal serum ratio was 1.12 (15.2) for 160 mother–fetal pairs, in which BPA was detected in both samples. The placenta-, maternal urine-, neonatal urine-, and breast milk-to-maternal serum ratios were 0.28 (5.31), 1.79 (29.9), 1.98 (28.2), and 0.51 (10.5), respectively. In addition, the median (95th percentile) cord serum-to-placenta ratio was 4.03 (45.8), and the neonatal urine-to-cord serum ratio was 1.95 (25.6). The 95th percentile values were 14–20-fold greater than the medians. Urine contained the highest BPA concentrations, followed by serum, breast milk, and the placenta. The variations of BPA ratio show individual differences in the amounts of BPA delivered from mother to fetus.
AB - Bisphenol A (BPA) exposure during the perinatal and postnatal periods increases the susceptibility to disease over the life cycle. However, information on the BPA delivered to fetuses or infants via the placenta and breastfeeding is limited. We determined the BPA exposure levels in various bodily fluids and tissues of pregnant women and described fetus and infant exposures to BPA based on associations and BPA ratios in mother–neonate paired samples. Maternal serum, urine, placenta, breast milk, cord serum, and neonatal urine samples were collected from 318 mother–neonate pairs at six university hospitals in Korea. BPA levels were detected using liquid chromatography tandem mass spectrometry. The ratios of the BPA levels in the other sample types to the levels in maternal serum were calculated. BPA was detected in 79.5–100% of the maternal and fetal samples. The median BPA concentration in the samples decreased in the order of neonatal urine (4.75 ng/mL), maternal urine (2.86 ng/mL), cord serum (1.71 ng/mL), maternal serum (1.56 ng/mL), breast milk (0.74 ng/mL), and the placenta (0.53 ng/g). We estimated the ratios of BPA levels in the other sample types to those in maternal serum. The median (95th percentile) cord serum-to-maternal serum ratio was 1.12 (15.2) for 160 mother–fetal pairs, in which BPA was detected in both samples. The placenta-, maternal urine-, neonatal urine-, and breast milk-to-maternal serum ratios were 0.28 (5.31), 1.79 (29.9), 1.98 (28.2), and 0.51 (10.5), respectively. In addition, the median (95th percentile) cord serum-to-placenta ratio was 4.03 (45.8), and the neonatal urine-to-cord serum ratio was 1.95 (25.6). The 95th percentile values were 14–20-fold greater than the medians. Urine contained the highest BPA concentrations, followed by serum, breast milk, and the placenta. The variations of BPA ratio show individual differences in the amounts of BPA delivered from mother to fetus.
KW - BPA ratio
KW - Bisphenol A
KW - Neonates
KW - Pregnant women
KW - Tissue distribution
UR - http://www.scopus.com/inward/record.url?scp=85034609435&partnerID=8YFLogxK
U2 - 10.1016/j.scitotenv.2017.10.042
DO - 10.1016/j.scitotenv.2017.10.042
M3 - Article
C2 - 29146078
AN - SCOPUS:85034609435
SN - 0048-9697
VL - 626
SP - 1494
EP - 1501
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -