Bisphenol A inhibits penile erection via alteration of histology in the rabbit

D. G. Moon; D. J. Sung; Y. S. Kim; J. Cheon; J. J. Kim

doi:10.1038/sj.ijir.3900734

Bisphenol A inhibits penile erection via alteration of histology in the rabbit

D. G. Moon, D. J. Sung, Y. S. Kim, J. Cheon, J. J. Kim

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.

Original language	English
Pages (from-to)	309-316
Number of pages	8
Journal	International Journal of Impotence Research
Volume	13
Issue number	5
DOIs	https://doi.org/10.1038/sj.ijir.3900734
Publication status	Published - 2001

Bibliographical note

Funding Information:
This study was supported by Korea University Medical Science Research Center Grant 1999 and Ministry of Education in Korea.

Keywords

Bisphenol A
Erection
Penis
Xenoestrogen

ASJC Scopus subject areas

Urology

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10.1038/sj.ijir.3900734

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title = "Bisphenol A inhibits penile erection via alteration of histology in the rabbit",

abstract = "Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.",

keywords = "Bisphenol A, Erection, Penis, Xenoestrogen",

author = "Moon, {D. G.} and Sung, {D. J.} and Kim, {Y. S.} and J. Cheon and Kim, {J. J.}",

note = "Funding Information: This study was supported by Korea University Medical Science Research Center Grant 1999 and Ministry of Education in Korea.",

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doi = "10.1038/sj.ijir.3900734",

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AU - Moon, D. G.

AU - Sung, D. J.

AU - Kim, Y. S.

AU - Cheon, J.

AU - Kim, J. J.

N1 - Funding Information: This study was supported by Korea University Medical Science Research Center Grant 1999 and Ministry of Education in Korea.

PY - 2001

Y1 - 2001

N2 - Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.

AB - Despite extensive research into the toxicity of bisphenol A (BPA), no report of its effect on erectile function exists. We performed this study to investigate the effect of BPA on erectile function. New Zealand white rabbits were treated intraperitoneally with 150 mg/kg of BPA every other day for 12 days (cumulative dose of 900 mg/kg). Four and 8 weeks after administration of BPA, the contractions and relaxation of cavernosal tissue strips were significantly suppressed in the BPA-treated animals compared to the control animals. Histologically, thickening of tunica albuginea, subtunical deposition of fat and decreased sinusoidal space with consequent increase of trabecular smooth muscle content were observed in the BPA-treated animals. These results suggest that xenoestrogen BPA may affect the erectile function through evident histological changes of the penis.

KW - Bisphenol A

KW - Erection

KW - Penis

KW - Xenoestrogen

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VL - 13

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Bisphenol A inhibits penile erection via alteration of histology in the rabbit

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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