Blood plasma separation using microfluidic guiding channel in a continuous fashion

Ali Karimi, Honggu Chun, Yang Jun Kang, Gyeong Bok Jung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Since plasma proteins are varied depending on diseases states, its continuous monitoring has been considered as effective diagnostic tool. In this study, a simple and efficient method for separate plasma and red blood cells (RBCs) from blood sample is proposed with a microfluidic device. To separate plasma in continuous way, microfluidic guiding channel is designed by connecting two channels with different heights in parallel, and employs inertial force and Zweifach–Fung bifurcation law. Due to its unique geometry, most RBCs flowed inside wall region with higher height. Then, plasma is collected from center region with lower height. As a result, the efficiency of plasma separation is achieved over 90 %. Furthermore, it is remained constant, even up to high value of 40% hematocrit. In the near future, the proposed method will be integrated with a lab-on-a-chip for diagnosing diseases.

Original languageEnglish
Title of host publicationEuropean Conference on Biomedical Optics, ECBO_2019
PublisherOptica Publishing Group (formerly OSA)
ISBN (Print)9781510628397
DOIs
Publication statusPublished - 2019
EventEuropean Conference on Biomedical Optics, ECBO_2019 - Munich, Netherlands
Duration: 2019 Jun 232019 Jun 25

Publication series

NameOptics InfoBase Conference Papers
VolumePart F142-ECBO 2019
ISSN (Electronic)2162-2701

Conference

ConferenceEuropean Conference on Biomedical Optics, ECBO_2019
Country/TerritoryNetherlands
CityMunich
Period19/6/2319/6/25

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A3B03931548).

Publisher Copyright:
© SPIE-OSA 2019

Keywords

  • Inertial force
  • Microfluidics
  • Plasma separation
  • Point-of-care diagnosis
  • Zweifach-Fung effect

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials

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